董江丽

中国农业大学农业生物技术国家重点实验室教授，博士生导师。1996年在内蒙古大学获得理学硕士学位，2005年中国农业大学获得博士学位。2009-2010在美国爱荷华州立大学访问学者一年。主要研究领域是豆科功能基因组研究和分子设计育种，研究团队搭建了完整的豆科植物基因组学、蛋白组学、功能基因组研究、TALEN和CRISPR-cas9突变体研究、分子设计育种技术平台。建立了苜蓿非生物胁迫转录组数据库、建立了完整的基因组数据平台。研究团队挖掘了一批关键基因并深入研究了其调控机制，解析了苜蓿抵抗非生物胁迫的调控网络；首次揭示了质膜定位的转录因子在干旱胁迫下进入细胞核的分子机制。发现了多个参与结瘤固氮的新基因，揭示了DMI2-PUB2通过磷酸化和泛素化负反馈环调控苜蓿结瘤内稳态的分子机制。研究组搭建了同时实现多个目标基因的过表达、干扰、标记基因删除的多基因转化技术平台，并利用这些平台实现了8个外源基因的共表达；培育了高异黄酮和单宁苜蓿、高纤维素低木质素苜蓿、高含硫氨基酸苜蓿新材料；培育了优质抗逆的水稻、棉花新材料和新种质。相关研究成果在全国居于领先水平。在The plant Cell, plant physiology，New Phytologist，Plant biotechnology journal，Plant cell and environment, Journal of Viology，等期刊发表学术论文20多篇。授权发明专利14项。

发表论文：

LIU，J，DENG，J，ZHU，F，LI，Y，LU，Z，QIN，P，WANG,T*，DONG, J* The MtDMI2-MtPUB2 negative feedback loop plays a role in rodulation homeostasis，Plant Physiol, 2018, 176, 3003-3026

DUAN, M,ZHANG,R,ZHU，F，ZHANG, Z，GOU，L，WEN，J， DONG, J*, WANG, T*A lipid-anchored nac transcription factor is translocated into the nucleus and activates glyoxalase I expression during drought stress.The Plant Cell,2017,29,1748-1772

FENG, H, LI,X, SONG,W, DUAN, M, CHEN, H, WANG,T, DONG, J*Oral administration of a seed-based bivalent rotavirus vaccine containing vp6 and nsp4 induces specific immune responses in mice.FRONTIERS IN PLANT SCIENCEdoi: 10.3389/fpls.2017.00910

ZHANG, Z, HU, X, ZHANG, Y, MIAO, Z, XIE, C, MENG, X, DENG, J, WEN, J, MYSORE, K.S, FRUGIER, F, WANG, T, DONG, J*.  Opposing Control by Transcription FactorsMYB61 andMYB3 Increases Freezing Tolerance by Relieving C-Repeat Binding Factor Suppression. Plant Physiol, 2016, 172, 1306-1323

GOU, L, ZHANG, R, MA, L, ZHU, F, DONG, J*, WANG, T*. Multigene synergism increases the isoflavone and proanthocyanidin contents of Medicago truncatula. Plant Biotechnol J, 2016.14,915-925

LI, H, MA, D, JIN, Y, TU, Y, LIU, L, LENG, C, DONG, J*, WANG, T*. Helper component-proteinase enhances the activity of 1-deoxy-D-xylulose-5-phosphate synthase and promotes the biosynthesis of plastidic isoprenoids in Potato virus Y-infected tobacco. Plant Cell Environ, 2015, 38: 2023-2034.

MIAO, Z, XU, W, LI, D, HU, X, LIU, J, ZHANG, R, TONG, Z, DONG, J, SU, Z, ZHANG, L, SUN, M, LI, W, DU, Z, HU, S*, WANG, T*. De novo transcriptome analysis of Medicago falcata reveals novel insights about the mechanisms underlying abiotic stress-responsive pathway. BMC Genomics, 2015, 16: 818.

TONG, Z, LI, H, ZHANG, R, MA, L, DONG, J, WANG, T*. Co-downregulation of the hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transferase and coumarate 3-hydroxylase significantly increases cellulose content in transgenic alfalfa (Medicago sativa L.). Plant Science, 2015, 239: 230-237.

MIAO, Z, LI, D, ZHANG, Z, DONG, J, SU, Z*, WANG, T*. Medicago truncatula transporter database: a comprehensive database resource for M. truncatula transporters. BMC Genomics, 2012, 13: 60.

XIE, C, ZHANG, R, QU, Y, MIAO, Z, ZHANG, Y, SHEN, X, WANG, T, DONG, J*. Overexpression of MtCAS31 enhances drought tolerance in transgenic Arabidopsis by reducing stomatal density. New Phytologist, 2012, 195: 124-135.

LI, D, ZHANG, Y, HU, X, SHEN, X, MA, L, SU, Z, WANG, T, DONG, J*. Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses. BMC Plant Biology, 2011, 11: 109.

MA, L, DONG, J, JIN, Y, CHEN, M, SHEN, X, WANG, T*. RMDAP: a versatile, ready-to-use toolbox for multigene genetic transformation. Public Library of Science ONE, 2011, 6: e19883.

TIAN, J, ZHANG, X, LIANG, B, LI, S, WU, Z, WANG, Q, LENG, C, DONG, J*, WANG, T. Expression of baculovirus anti-apoptotic genes p35 and op-iap in cotton (Gossypium hirsutum L.) enhances tolerance to verticillium wilt. Public Library of Science ONE, 2010, 5: e14218.

LI, D, SU, Z, DONG, J*, WANG, T. An expression database for roots of the model legume Medicago truncatula under salt stress. BMC Genomics, 2009, 10: 517.

JIN, Y, MA, D, DONG, J, JIN, J, LI, D, DENG, C, WANG, T*. HC-Pro protein of Potato virus Y can interact with three Arabidopsis 20S proteasome subunits in planta. Journal of Virology, 2007, 81: 12881-12888.

DONG, J , LIANG, B, JIN, Y, ZHANG, W, WANG, T*. Oral immunization with pBsVP6-transgenic alfalfa protects mice against rotavirus infection. Virology, 2005, 339: 153-163.

（一）苜蓿抗逆分子机制研究

（二）苜蓿-根瘤菌共生固氮调控机制研究

（三）苜蓿分子育种技术创新和新品种培育

本科生课程：近十年课程数据
研究生课程：近十年课程数据

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