郭伟龙

郭伟龙，教授、博士生导师，国家自然科学基金优秀青年项目获得者（2023）。

【教育研究经历】

2005.09-2009.07    北京邮电大学  学士

2009.09-2014.07    清华大学          博士

2012.09-2013.10    UCLA               联合培养研究生

2014.07-2016.06    北京大学          博士后研究

2016.06-2017.12   中国农业大学   讲师

2017.12-2023.12   中国农业大学   副教授

2023.12-今            中国农业大学   教授

【主要研究方向】多倍体小麦复杂基因组与种质资源解析。近年来，先后主持国家自然科学基金青年项目、面上项目、优青项目；以第一作者或通讯作者在Nature Communications（2020/2022）、Molecular Plant（2020/2023a/2023b/2024a/2024b）、Genome Biology（2024）、 New Phytologist（2024）、Plant Physiology（2022/2023）、Plant Communications（2024a/2024b）、JGG（2023）、Bioinformatics（2018）、Nucleic Acids Research（2013）、aBIOTECH（2024）、GigaScience（2018）等高水平期刊发表一系列研究论文。围绕小麦种质资源基因组学解析进行研究，在小麦演化驯化基因组学基础、优异种质资源形成规律解析、多组学数据整合挖掘功能基因方向取得了一系列进展。

【研究思路】目前以小麦为研究对象，结合生物信息学、基因组学、人工智能等多学科交叉手段，以方法和技术创新为驱动，围绕作物多组学大数据整合与挖掘、小麦基因组变异与演化规律、小麦种质资源构成与优异基因利用、小麦智能设计育种等问题，开展一系列原创性研究。主要研究包括三个层面：

（1）结合小麦多组学数据进行研究，回答多倍体小麦的驯化与育种选择、种质资源构成与演变、复杂基因调控网络等方面的科学问题；

（2）针对小麦的复杂基因组解析和海量组学数据整合问题，结合算法和统计学模型，设计和开发新的生物信息学计算工具；

（3）对小麦的基因组、转录组、表观组和泛基因组的海量数据进行整合分析，搭建数据可视化平台，旨在提高小麦多组学研究效率。

【英文个人主页】 http://guoweilong.github.io 

已开发的原创算法和工具

BS-Seeker2 (2013) http://www.pellegrini.mcdb.ucla.edu/BS_Seeker2/ 

CGmapTools (2018) https://cgmaptools.github.io/ 

SnpHub (2020) https://guoweilong.github.io/SnpHub/ 

GeneTribe (2020) https://chenym1.github.io/genetribe/ 

ggComp (2022) https://zack-young.github.io/ggComp/ 

IntroBlocker (2022) https://wangzihell.github.io/IntroBlocker/ 

IGTminer (2023) https://chenym1.github.io/IGTminer/ 

PanSK (2024) https://zhangzhaoheng24.github.io/PanSK/ 

lcQTH (2024) https://esctrionsit.github.io/lcQTH/ 

已搭建的小麦基因组学数据库

Wheat-SnpHub-Portal (2020) http://wheat.cau.edu.cn/Wheat_SnpHub_Portal/ 

WheatUnion (2020) http://wheat.cau.edu.cn/Wheat_SnpHub_Portal/ 

Triticeae-GeneTribe/TGT (2020)http://wheat.cau.edu.cn/TGT/ 

WheatCompDB (2022) http://wheat.cau.edu.cn/WheatCompDB/ 

wGRN（2023)  http://wheat.cau.edu.cn/wGRN/ 

pNOGmap (2023) http://wheat.cau.edu.cn/pNOGmap/ 

wLNCdb (2023) http://wheat.cau.edu.cn/wLNCdb/ 

WheatCNVb (2024) http://wheat.cau.edu.cn/WheatCNVb/ 

主讲课程：

本科生：

    1.《作物生物信息学》

    2.《生物信息学》

    3.《科技论文写作》

研究生：

    1.《作物遗传育种专业英语》

论文著作（★ 第一作者/通信作者文章）

英文期刊论文：

• 2024 •

★81. Zihao Wang *, Wenxi Wang, Yachao He, Xiaoming Xie, Zhengzhao Yang, Xiaoyu Zhang, Jianxia Niu, Huiru Peng, Yingyin Yao, Chaojie Xie, Mingming Xin, Zhaorong Hu, Qixin Sun, Zhongfu Ni#, Weilong Guo#. (2024) On the evolution and genetic diversity of bread wheat D genome, Molecular Plant. 

(# Corresponding Authors)

80. Dejie Du, Zhaoju Li, Jun Yuan†, Fei He, Xiongtao Li, Naijiao Wang, Renhan Li, Wensheng Ke, Dongxue Zhang, Zhaoyan Chen, Zihao Jiang, Yunjie Liu, Lingling Chai, Jie Liu, Zhaorong Hu, Weilong Guo, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni, Mingming Xin. (2024) The TaWAK2-TaNAL1-TaDST pathway regulates leaf width via cytokinin signaling in wheat, Science Advances, 10(35):eadp5541.

★79. Jianxia Niu*, Wenxi Wang*, Zihao Wang*, Zhe Chen, Xiaoyu Zhang, Zhen Qin, Lingfeng Miao, Zhengzhao Yang, Chaojie Xie, Mingming Xin, Huiru Peng, Yingyin Yao, Jie Liu, Zhongfu Ni, Qixin Sun#, Weilong Guo#. (2024) Tagging large CNV blocks in wheat boosts digitalization of germplasm resources by ultra-low-coverage sequencing, Genome Biology, 25(1):171.

(# Corresponding Authors)

[link] WheatCNVb: http://wheat.cau.edu.cn/WheatCNVb/ 

★78.Wenxi Wang*, Zhe Chen, Zhengzhao Yang, Zihao Wang, Jilu Liu, Jie Liu, Huiru Peng, Zhenqi Su, Zhongfu Ni, Qixin Sun, Weilong Guo#. (2024) lcQTH: rapid quantitative trait mapping through tracing parental haplotype with ultra-low-coverage sequencing, Plant Communications, . (# Corresponding Authors)

[link]lcQTH: https://esctrionsit.github.io/lcQTH/ 

★77. Zhaoheng Zhang*, Dan Liu*, Binyong Li, Wenxi Wang, Jize Zhang, Mingming Xin, Zhaorong Hu, Jie Liu, Jinkun Du, Huiru Peng, Chenyang Hao, Xueyong Zhang, Zhongfu Ni, Qixin Sun, Weilong Guo#, Yingyin Yao#. (2024) A k-mer-based pangenome approach for cataloging seed-storage-protein genes in wheat to facilitate genotype-to-phenotype prediction and improvement of end-use quality, Molecular Plant, . (# Corresponding Authors)

[Link] PanSK: https://github.com/ZhangZhaoheng24/kmer_scan

76. Zhaoyan Chen, Xuanshuang Li, Fei He, Bin Liu, Weiya Xu, Lingling Chai, Xuejiao Cheng, Long Song, Weilong Guo, Zhaorong Hu, Zhenqi Su, Jie Liu, Mingming Xin, Huiru Peng, Yingyin Yao, Qixin Sun, Jiewen Xing, Zhongfu Ni. (2024) Positional cloning and characterization reveal the role of TaSRN-3D and TaBSR1 in the regulation of seminal root number in wheat, New Phytologist  242(6):2510-2523.

75. Weiwei Mao, Xiaobo Wang, Yongming Chen, Yongfa Wang, Liang Ma, Xiaoming Xie, Xiaojia Wu, Jin Xu, Yuqi Zhang, Yue Zhao, Xuejun Tian, Weilong Guo, Zhaorong Hu, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng. (2024) Map-based cloning and characterization reveal that an R2R3 MYB gene confers red glume in wheat, The Crop Journal, .

74. Jinpeng Li, Xingbei Liu, Shumin Chang, Wei Chu, Jingchen Lin, Hui Zhou, Zhuoran Hu, Mancang Zhang, Mingming Xin, Yingyin Yao, Weilong Guo, Xiaodong Xie, Huiru Peng, Zhongfu Ni, Qixin Sun, Yu Long, Zhaorong Hu. (2024) The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat, Science Advances, 10(15):eadk4027.

73. Wei Chu, Shumin Chang, Jingchen Lin, Chenji Zhang, Jinpeng Li, Xingbei Liu, Zehui Liu, Debiao Liu, Qun Yang, Danyang Zhao, Xiaoyu Liu, Weilong Guo, Mingming Xin, Yingyin Yao, Huiru Peng, Chaojie Xie, Zhongfu Ni, Qixin Sun, Zhaorong Hu. (2024) Methyltransferase TaSAMT1 mediates wheat freezing tolerance by integrating brassinosteroid and salicylic acid signaling, The Plant Cell, .

★72. Yongfa Wang*, Zihao Wang*, Yongming Chen, Tianyu Lan, Xiaobo  Wang, Gang Liu, Mingming Xin, Zhaorong Hu, Yingyin Yao, Zhongfu Ni,  Qixin Sun,  Weilong Guo#, Huiru Peng#. (2024)   Genomic insights into the origin and evolution of spelt (Triticum spelta L.) as a valuable gene pool for modern wheat breeding,  Plant Communications, .  

(# Corresponding Authors) 

71. Wenxin Wei, Nannan Liu, Shengnan Zhang, Jing Zhang, Wei Pan, Xiaoming Xie, Zuhuan Yang, Junna Sun, Jun Ma, Zhaorong Hu, Weilong Guo, Qiaoling Luo, Jingzhong Xie, Fei He, Yinghui Li, Chaojie Xie, Qixin Sun. (2024) Mapping of powdery mildew resistance genes transferred to common wheat from wild emmer wheat revealed three functional Pm60 haplotypes, Crop Journal, .

70. Jie Cao, Zhen Qin, Guangxian Cui, Zhaoyan Chen, Xuejiao Cheng, Huiru Peng, Yingyin Yao, Zhaorong Hu, Weilong Guo, Zhongfu Ni, Qixin Sun, Mingming Xin. (2024) Natural variation of STKc_GSK3 kinase TaSG- D1 contributes to heat stress tolerance in Indian dwarf wheat, Nature Communications, 15:2097.

★69. Lingfeng Miao*, Weiya Xu*, Yanhong Liu, Xiangyi Huang, Zhe Chen, Huifang Wang, Zihao Wang, Yongming Chen, Qingxin Song, Jing Zhang, Fangpu Han, Huiru Peng, Yingyin Yao, Mingming Xin, Zhaorong Hu, Zhongfu Ni, Qixin Sun, Jiewen Xing#, Weilong Guo#. (2024) Reshaped DNA methylation cooperating with homoeolog- divergent expression promotes improved root traits in synthesized tetraploid wheat, New Phytologist, . 

(# Corresponding Authors)

★68. Yongming Chen*, Wenxi Wang*, Zhengzhao Yang, Huiru Peng, Zhongfu Ni, Qixin Sun, Weilong Guo#. (2024) Innovative computational tools provide new insights into the polyploid wheat genome, aBIOTECH, . (# Corresponding Authors)

(Review)

[Resource] Tutorial page: http://wheat.cau.edu.cn/resources/tutorial.html

• 2023 •

67. Yuzhi Zhu, Zijie Wang, Zanchen Zhou, Yuting Liu, Xiang Gao, Weilong Guo, Junpeng Shi. (2023) HEMU: an integrated comparative genomics database and analysis platform for Andropogoneae grasses, Plant Communications, .

66. Jianing Zhang, Zhaoheng Zhang, Ruijie Zhang, Changfeng Yang, Xiaobang Zhang, Siyuan Chang, Qian Chen, Vincenzo Rossi, Long Zhao, Jun Xiao, Mingming Xin, Jinkun Du, Weilong Guo, Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2024) Type I MADS-box transcription factor TaMADS-GS regulates grain size by stabilizing cytokinin signalling during endosperm cellularization in wheat, Plant Biotechnology Journal, 22(1):200-215.

65. Wenjia Zhang, Zhaoheng Zhang, Qian Chen, Zihao Wang, Wanjun Song, Kai Yang, Mingming Xin, Zhaorong Hu, Jie Liu, Huiru Peng, Jinsheng Lai, Weilong Guo, Zhongfu Ni, Qixin Sun, Jinkun Du, Yingyin Yao. (2023) TMutation of a highly conserved amino acid in RPM1 causes leaf yellowing and premature senescence in wheat, Theoretical and Applied Genetics, 136(12):254.

64. Xiongtao Li, Beilu Cao, Dejie Du, Long Song, Lulu Tian, Xiaoming Xie, Zhaoyan Chen, Yanpeng Ding, Xuejiao Cheng, Yingyin Yao, Weilong Guo, Zhenqi Su, Qixin Sun, Zhongfu Ni, Lingling Chai, Jie Liu. (2023) TaACTIN7-D regulates plant height and grain shape in bread wheat, Journal of Genetics and Genomics, 50(11):895-908.

63. Weiya Xu, Yongming Chen, Bin Liu, Qiuyuan Li, Yilan Zhou, Xuanshuang Li, Weilong Guo, Zhaorong Hu, Zhenshan Liu, Mingming Xin, Yingyin Yao, Mingshan You, Huiru Peng, Zhongfu Ni, Jiewen Xing. (2023) TaANR1-TaMADS25 module regulates lignin biosynthesis and root development in wheat (Triticum aestivum L.), Journal of Genetics and Genomics, 50(11):917-920.

★62. Zihao Wang, Lingfeng Miao, Yongming Chen, Huiru Peng, Zhongfu Ni, Qixin Sun, Weilong Guo#. (2023) Deciphering the evolution and complexity of wheat germplasm from a genomic perspective, Journal of Genetics and Genomics, 50(11):846-860. 

(# Corresponding Authors)

(Review)

★61. Zhaoheng Zhang *, Ruijie Zhang *, Fengfan Meng, Yongming Chen, Wenxi Wang, Kai Yang, Yujiao Gao, Mingming Xin, Jinkun Du, Zhaorong Hu, Zhongfu Ni, Qixin Sun, Weilong Guo#, Yingyin Yao#. (2023) A comprehensive atlas of long non-coding RNAs provides insight into grain development in wheat, Seed Biology, 2:12. (# Corresponding Authors)

[Datbase] wLNCdb: http://wheat.cau.edu.cn/wLNCdb/

60. Haoran Wang, Man Feng, Yujie Jiang, Dejie Du, Chaoqun Dong, Zhaoheng Zhang, Wenxi Wang, Jing Liu, Xiangqing Liu, Sufang Li, Yongming Chen, Weilong Guo, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng, Jie Liu (2023) Thermosensitive SUMOylation of TaHsfA1 defines a dynamic ON/OFF molecular switch for the heat stress response in wheat, The Plant Cell, koad192.

★59. Yongming Chen, Yiwen Guo, Xiaoming Xie, Zihao Wang, Lingfeng Miao, Zhengzhao Yang, Yuannian Jiao, Chaojie Xie, Jie Liu, Zhaorong Hu, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng#, Weilong Guo#. (2023) Pangenome-based trajectories of intracellular gene transfers in Poaceae unveil high cumulation in Triticeae, Plant Physiology, kiad319. 

(# Corresponding Authors)

[Software] IGTminer: https://chenym1.github.io/IGTminer/

[Datbase] pNOGmap: http://wheat.cau.edu.cn/pNOGmap/

★58.   Dawa Dondup*, Yang Yang*, Dongdong Xu*, Lhundrup Namgyal, Zihao   Wang, Xia Shen, Tsechoe Dorji, Nyima kyi, Lhakpa Drolma, Liyun Gao,  Zhuo  Ga, Zha Sang, Zhuo Ga, Wang Mu, Pubu Zhuoma, Xiongnu Taba,  Guocheng  Jiao, Wenhua Liao, Yawei Tang, Xingquan Zeng, Zhaxi Luobu,  Yufeng Wu,  Chunchao Wang, Jing Zhang, Zengjun Qi#, Weilong Guo#,  Ganggang Guo#. (2023) Genome diversity and highland-adaptative  variation in Tibet barley landrace population of China, Frontiers in Plant Science, 14:1189642. 

(# Corresponding Authors; * Joint First Authors)

57.   Long Song, Jie Liu, Beilu Cao, Bin Liu, Xiaoping Zhang, Zhaoyan Chen,   Chaoqun Dong, Xiangqing Liu, Zhaoheng Zhang, Wenxi Wang, Lingling Chai, Jing Liu, Jun Zhu, Shubin Cui, Fei He, Huiru Peng, Zhaorong Hu, Zhenqi   Su, Weilong Guo, Mingming Xin, Yingyin Yao, Yong Yan, Yinming Song, Guihua Bai, Qixin Sun, Zhongfu Ni. (2023) Reducing brassinosteroid signalling enhances grain yield in semi-dwarf wheat, Nature, 617(7959):118-124.

★56.   Zhichao Yu*, Yongming Chen*, Yong Zhou*, Yulu Zhang, Mengyuan Li,   Yidan Ouyang, Dmytro Chebotarov, Ramil Mauleon, Hu Zhao, Weibo Xie, Kenneth L. McNally, Rod A. Wing#, Weilong Guo#,   Jianwei Zhang#. (2023) Rice Gene Index: A comprehensive pan-genome database for comparative and functional genomics of Asian rice, Molecular Plant, 16(5):798-801. 

(# Corresponding Authors; * Joint First Authors)

[Software] RGI: https://riceome.hzau.edu.cn/

55. Xiaobo Wang, Jinbo Zhang, Weiwei Mao, Panfeng Guan, Yongfa Wang, Yongming Chen, Wangqing Liu, Weilong Guo, Yingyin Yao, Zhaorong Hu, Mingming Xin, Zhongfu Ni, Qixin Sun, Huiru Peng. (2023) Association mapping identifies loci and candidate genes for grain-related traits in spring wheat in response to heat stress, Plant Science, 331:111676.

54.   Wensheng Ke, Jiewen Xing, Zhaoyan Chen, Yidi Zhao, Weiya Xu, Lulu  Tian,  Jinquan Guo, Xiaoming Xie, Dejie Du, Zihao Wang, Yufeng Li, Jin  Xu,  Mingming Xin, Weilong Guo,   Zhaorong Hu, Zhenqi Su, Jie Liu, Huiru Peng, Yingyin Yao, Qixin Sun,  Zhongfu Ni. (2023) The TaTCP4/10-B1 cascade regulates awn elongation in   wheat (Triticum aestivum L.), Plant Communications, 4:100590.

53. Yiwen Guo, Yongming Chen, Yongfa Wang, Xiaojia Wu, Xiaoyu Zhang, Weiwei Mao, Hongjian Yu, Kai Guo, Jin Xu, Liang Ma, Weilong Guo, Zhaorong Hu, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru  Peng. (2023) The translational landscape of bread wheat during grain development, The Plant Cell, 35(6):1848-1867.

52.   Guoyu Liu, Runqi Zhang, Sen Li, Rehmat Ullah, Fengping Yang, Zihao   Wang, Weilong Guo, Mingshan You, Baoyun Li, Chaojie Xie, Liangsheng Wang, Jie Liu, Zhongfu Ni, Qixin Sun, Rongqi Liang. (2023) TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat, SCIENCE CHINA Life Sciences, 66(7):1647-1664.

51.   Hongxia Liu, Xuemei Si, Zhenyu Wang, Liangjing Cao, Lifeng Gao,  Xiaolong Zhou, Wenxi Wang, Ke Wang, Chengzhi Jiao, Lei Zhuang, Yunchuan   Liu, Jian Hou, Tian Li, Chenyang Hao, Weilong Guo,   Jun Liu, Xueyong Zhang. (2023) TaTPP-7A positively feedback regulates grain filling and wheat grain yield through T6P-SnRK1 signaling pathway and sugar-ABA interaction, Plant Biotechnology Journal, 21(6):1159-1175.

50. Dan Liu, Huaimao Yang, Zhaoheng Zhang, Qian Chen, Weilong Guo, Vincenzo Rossi, Mingming Xin, Jinkun Du, Zhaorong Hu, Jie Liu, Huiru   Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2023) An elite γ-gliadin   allele improves end-use quality in wheat, New Phytologist, 239(1):87-101.

★49.  Yongming Chen*, Yiwen Guo*, Panfeng Guan, Yongfa Wang, Xiaobo Wang,   Zihao Wang, Zhen Qin, Shengwei Ma, Mingming Xin, Zhaorong Hu, Yingyin   Yao, Zhongfu Ni, Qixin Sun, Weilong Guo#, Huiru Peng#. (2023) A wheat integrative regulatory network from large-scale complementary functional datasets enables trait-associated  gene discovery for crop improvement, Molecular Plant, 16(2):393-414. 

(# Corresponding Authors; * Joint First Authors)

[Database] wGRN: http://wheat.cau.edu.cn/wGRN/

• 2022 •

48. Mei Zheng, Jinpeng Li, Chaowu Zeng, Xingbei Liu, Wei Chu, Jingchen Lin, Fengzhi Wang, Weiwei Wang, Weilong Guo,   Mingming Xin, Yingyin Yao, Huiru Peng, Zhongfu Ni, Qixin Sun, Zhaorong Hu. (2022) Subgenome-biased expression and functional diversification of  a Na+/H+ antiporter homoeologs in salt tolerance of polyploid wheat,  Frontiers in Plant Science, 13:1072009.

47. Changfeng Yang, Qian Chen, Mingming Xin, Zhenqi Su, Jinkun Du, Weilong Guo,   Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao.   (2022) A highly conserved amino acid in high molecular weight glutenin   subunit 1Dy12 contributes to gluten functionality and processing  quality  in wheat, Journal of Genetics and Genomics, 50(11):909-912.

46. Siyuan Chang, Qian Chen, Tao Yang, Binyong Li, Mingming Xin, Zhenqi Su, Jinkun Du, Weilong Guo,   Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2022) Pinb-D1p is an elite allele for improving end-use quality in wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 135(12):4469–4481.

45.   Jun Xiao, Bao Liu, Yingyin Yao, Zifeng Guo, Haiyan Jia, Lingrang Kong, Aimin Zhang, Wujun Ma, Zhongfu Ni, Shengbao Xu, Fei Lu, Yuannian Jiao,   Wuyun Yang, Xuelei Lin, Silong Sun, Zefu Lu, Lifeng Gao, Guangyao  Zhao,  Shuanghe Cao, Qian Chen, Kunpu Zhang, Mengcheng Wang, Meng Wang,   Zhaorong Hu, Weilong Guo,  Guoqiang Li, Xin Ma, Junming Li, Fangpu Han, Xiangdong Fu, Zhengqiang   Ma, Daowen Wang, Xueyong Zhang, Hong-Qing Ling, Guangmin Xia, Yiping   Tong, Zhiyong Liu, Zhonghu He, Jizeng Jia, Kang Chong. (2022) Wheat   genomic study for genetic improvement of traits in China, Science China Life Sciences, 65(9):1718–1775.

44.   Na Song, Jingchen Lin, Xingbei Liu, Zehui Liu, Debiao Liu, Wei Chu, Jinpeng Li, Yongming Chen, Shumin Chang, Qun Yang, Xiaoyu Liu, Weilong Guo,   Mingming Xin, Yingyin Yao, Huiru Peng, Zhongfu Ni, Chaojie Xie, Qixin   Sun, Zhaorong Hu. (2022) Histone acetyltransferase TaHAG1 interacts  with  TaPLATZ5 to activate TaPAD4 expression and positively contribute  to  powdery mildew resistance in wheat, New Phytologist, 236(2):590-607.

43.   Jingchen Lin, Na Song, Debiao Liu, Xingbei Liu, Wei Chu, Jinpeng Li, Shumin Chang, Zehui Liu, Yongming Chen, Qun Yang, Xiaoyu Liu, Yingyin   Yao, Weilong Guo, Mingming Xin, Huiru Peng, Zhongfu Ni, Qixin Sun,  Zhaorong Hu. (2022) Histone acetyltransferase TaHAG1 interacts with   TaNACL to promote heat stress tolerance in wheat, Plant Biotechnology Journal, 20(9):1645-1647.

★42.   Zihao Wang, Wenxi Wang, Xiaoming Xie, Yongfa Wang, Zhengzhao Yang,   Huiru Peng, Mingming Xin, Yingyin Yao, Zhaorong Hu, Jie Liu, Zhenqi Su,   Chaojie Xie, Baoyun Li, Zhongfu Ni, Qixin Sun#, Weilong Guo#.   (2022) Dispersed emergence and protracted domestication of polyploid   wheat uncovered by mosaic ancestral haploblock inference, Nature Communications, 13:3891.

(# Corresponding Author)

[Software] IntroBlocker: https://wangzihell.github.io/IntroBlocker/

41.   Qian Chen, Changfeng Yang, Zhaoheng Zhang, Zihao Wang, Yongming Chen,   Vincenzo Rossi, Wei Chen, Mingming Xin, Zhenqi Su, Jinkun Du, Weilong Guo,   Zhaorong Hu, Jie Liu, Huiru Peng, Zhongfu Ni, Qixin Sun, Yingyin Yao.   (2022) Unprocessed wheat γ-gliadin reduces gluten accumulation   associated with the endoplasmic reticulum stress and elevated cell   death, New Phytologist, 236(1):146-164.

★40. Zhengzhao Yang*, Zihao Wang*, Wenxi Wang*, Xiaoming Xie, Lingling  Chai,  Xiaobo Wang, Xibo Feng, Jinghui Li, Huiru Peng, Zhenqi Su,  Mingshan  You, Yingyin Yao, Mingming Xin, Zhaorong Hu, Jie Liu, Rongqi  Liang,  Zhongfu Ni, Qixin Sun, Weilong Guo#. (2022) ggComp enables dissection of germplasm resources and construction of a multiscale germplasm network in wheat, Plant Physiology, 188(4):1950-1965.

(# Corresponding Author; * Joint First Authors)

[Software] ggComp: https://zack-young.github.io/ggComp/

[Database] WheatCompDB: http://wheat.cau.edu.cn/WheatCompDB/

39. Lingling Chai, Mingming Xin, Chaoqun Dong, Zhaoyan Chen, Huijie Zhai,   Junhong Zhuang, Xuejiao Cheng, Naijiao Wang, Jia Geng, Xiaobo Wang,   Ruolin Bian, Yingyin Yao, Weilong Guo,   Zhaorong Hu, Huiru Peng, Guihua Bai, Qixin Sun, Zhenqi Su, Jie Liu, Zhongfu Ni. (2022) A natural variation in Ribonuclease H-like gene underlies Rht8 to confer “Green Revolution” trait in wheat, Molecular Plant, 15(3):377-380.

38. Zhaoyan Chen, Wensheng Ke, Fei He, Lingling Chai, Xuejiao Cheng, Huanwen Xu, Xiaobo Wang, Dejie Du, Yidi Zhao, Xiyong Chen, Jiewen Xing, Mingming Xin, Weilong Guo, Zhaorong Hu, Zhenqi Su, Jie Liu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni. (2022) A single nucleotide deletion in the third exon of FT-D1 increases the spikelet number and delays heading date in wheat (Triticum aestivum L.), Plant Biotechnology Journal, 20(5):920-933.

• 2021 •

37. Shengwei Ma, Meng Wang, Jianhui Wu, Weilong Guo,   Yongming Chen, Guangwei Li, Yanpeng Wang, Weiming Shi, Guangmin Xia, Daolin Fu, Zhensheng Kang, Fei Ni. (2021) WheatOmics: A platform   combining multiple omics data to accelerate functional genomics studies in wheat, Molecular Plant, 14(12):1965-1968.

[Database] WheatOmics: http://wheatomics.sdau.edu.cn/

36. Zhiyu Feng, Long Song, Wanjun Song, Zhongqi Qi, Jun Yuan, Run Li, Haiming Han, Huifang Wang, Zhaoyan Chen, Weilong Guo,   Mingming Xin, Jie Liu, Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin  Sun,  Zhongfu Ni, Jiewen Xing. (2021) The decreased expression of GW2 homologous genes contributed to the increased grain width and thousand‑grain weight in wheat-Dasypyrum villosum 6VS·6DL translocation lines, Theoretical and Applied Genetics, 134(12):3873-3894.

35. Xiang Gao, Weipeng Mo, Junpeng Shi, Ning Song, Pei Liang, Jian Chen, Yiting Shi, Weilong Guo, Xinchen Li, Xiaohong Yang, Beibei Xin, Haiming Zhao, Weibin Song, Jinsheng  Lai.  (2021) HITAC-seq enables high-throughput cost-effective sequencing  of  plasmids and DNA fragments with identity-tracked, Journal of Genetics and Genomics, 48(8):671-680.

34. Qiang Zhang, Wenxin Wei, Xiangxi Zuansun, Shengnan Zhang, Chen Wang, Nannan Liu, Lina Qiu, Weidong Wang, Weilong Guo, Jun Ma, Huiru Peng, Zhaorong Hu, Qixin Sun, Chaojie Xie. (2021) Fine Mapping of the Leaf Rust Resistance Gene Lr65 in Spelt Wheat ‘Altgold’, Frontiers in Plant Science, 12:666921.

33. Lina Qiu, Nannan Liu, Huifang Wang, Xiaohan Shi, Feng Li, Qiang Zhang, Weidong Wang, Weilong Guo, Zhaorong Hu, Hongjie Li, Jun Ma, Qixin Sun, Chaojie Xie. (2021) Fine mapping of a powdery mildew resistance gene MlIW39 derived from wild emmer wheat (Triticum turgidum ssp. dicoccoides), Theoretical and Applied Genetics, 134(8):2469-2479.

32. Jing Liu, Zhaoyan Chen, Zhihui Wang, Zhaoheng Zhang, Xiaoming Xie,   Zihao Wang, Lingling Chai, Long Song, Xuejiao Cheng, Man Feng, Xiaobo   Wang, Yanhong Liu, Zhaorong Hu, Jiewen Xing, Zhenqi Su, Huiru Peng,   Mingming Xin, Yingyin Yao, Weilong Guo, Qixin Sun, Jie Liu, Zhongfu Ni. (2021) Ectopic expression of VRT-A2 underlies the origin of Triticum polonicum and Triticum petropavlovskyi with long outer glumes and grains, Molecular Plant, 14(9):1472-1488.

31. Dejie Du, Dongxue Zhang, Jun Yuan, Man Feng, Zhaoju Li, Zihao Wang,   Zhaoheng Zhang, Xiongtao Li, Wensheng Ke, Renhan Li, Zhaoyan Chen,   Lingling Chai, Zhaorong Hu, Weilong Guo, Jiewen Xing, Zhenqi Su, Huiru Peng, Mingming Xin, Yingyin Yao, Qixin Sun, Jie Liu, Zhongfu Ni. (2021) FRIZZY PANICLE defines a regulatory hub for simultaneously controlling spikelet formation and awn elongation in bread wheat, New Phytologist, 231(2):814-833.

30. Linghong Li, Lingling Chai, Huanwen Xu, Huijie Zhai, Tianya Wang,   Mingyi Zhang, Mingshan You, Huiru Peng, Yingyin Yao, Zhaorong Hu,   Mingming Xin, Weilong Guo, Qixin Sun, Xiyong Chen, Zhongfu Ni. (2021) Phenotypic characterization of the glossy1 mutant and fine mapping of GLOSSY1 in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics. 134(3):835-847.

29. Yujiao Gao, Kexin An, Weiwei Guo, Yongming Chen, Ruijie Zhang, Xue   Zhang, Siyuan Chang, Vincenzo Rossi, Fangming Jin, Xinyou Cao, Mingming   Xin, Huiru Peng, Zhaorong Hu, Weilong Guo,   Jinkun Du, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2021) The   endosperm-specific transcription factor TaNAC019 regulates glutenin and   starch accumulation and its elite allele improves wheat grain quality,  The Plant Cell. 33(3):603-622.

• 2020 and before •

28. Kuohai Yu, Man Feng, Guanghui Yang, Lv Sun, Zhen Qin, Jie Cao,  Jingjing  Wen, Haoran Li, Yan Zhou, Xiangping Chen, Huiru Peng, Yingyin  Yao,  Zhaorong Hu, Weilong Guo, Qixin Sun, Zhongfu Ni, Keith Adams, Mingming Xin. (2020) Changes in Alternative Splicing in Response to Domestication and Polyploidization in Wheat, Plant Physiology, 184(4):1955-1968.

★27. Yongming Chen, Wanjun Song, Xiaoming Xie, Zihao Wang, Panfeng Guan, Huiru Peng, Yuannian Jiao, Zhongfu Ni, Qixin Sun, Weilong Guo#.   (2020) A Collinearity-incorporating Homology Inference Strategy for   Connecting Emerging Assemblies in Triticeae Tribe as a Pilot Practice  in  the Plant Pangenomic Era, Molecular Plant, 13(12):1694-1708.

(# Corresponding Author)

[Software] GeneTribe: https://chenym1.github.io/genetribe/

[Database] Triticeae-GeneTribe (TGT):http://wheat.cau.edu.cn/TGT/

★26. Weilong Guo*,   Mingming Xin *, Zihao Wang *, Yingyin Yao, Zhaorong Hu, Wanjun Song,   Kuohai Yu, Yongming Chen, Xiaobo Wang, Panfeng Guan, Rudi Appels, Huiru   Peng#, Zhongfu Ni#, Qixin Sun#. (2020) Origin and adaptation to high   altitude of Tibetan semi-wild wheat, Nature Communications, 11:5085.

(# Corresponding Authors; * Joint First Authors)

[Resource] Zang817_Genome: http://wheat.cau.edu.cn/Zang1817_genome/

[Resource] SnpHub-NC20: http://wheat.cau.edu.cn/Wheat_SnpHub_Portal/balancer/?appname=snphub_NC20

★25. Wenxi Wang*, Zihao Wang*, Xintong Li, Zhongfu Ni, Zhaorong Hu, Mingming Xin, Huiru Peng, Yingyin Yao, Qixin Sun, Weilong Guo#.   (2020) SnpHub: an easy-to-set-up web server framework for exploring   large-scale genomic variation data in the post-genomic era with   applications in wheat, GigaScience, 9(6):giaa060.

(# corresponding author; * Joint First Authors)

Software: SnpHub, http://guoweilong.github.io/SnpHub/

Database: Wheat-SnpHub-Portal, http://wheat.cau.edu.cn/Wheat_SnpHub_Portal/

24. Lina Qiu, Huifang Wang, Yinghui Li, Weidong Wang, Yujia Liu, Junyi Mu, Miaomiao Geng, Weilong Guo, Zhaorong Hu, Jun Ma, Qixin Sun, Chaojie Xie. (2020) Fine Mapping of the Wheat Leaf Rust Resistance Gene LrLC10 (Lr13) and Validation of Its Co-segregation Markers, Frontiers in Plant Science, 11:470.

23. Feng Huang, Zhaoyan Chen, Dejie Du, Panfeng Guan, Lingling Chai, Weilong Guo, Zhaorong Hu, Mingming Xin, Huiru Peng, Yingyin Yao, Zhongfu Ni. (2020) Genome-wide linkage mapping of QTL for root hair length in a Chinese   common wheat population, The Crop Journal, 8(6):1049-1056.

22.   Jinghui Li, Shaozhe Wen, Chaofeng Fan, Minghu Zhang, Shuai Tian,   Wenjing Kang, Wenxin Zhao, Chan Bi, Qiuyan Wang, Shuang Lu, Weilong Guo, Zhongfu Ni, Chaojie Xie, Qixin Sun, Mingshan You. (2020)   Characterization of a major quantitative trait locus on the short arm  of  chromosome 4B for spike number per unit area in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 133(7):2259-2269.

21.   Xuejiao Cheng, Mingming Xin, Ruibin Xu, Zhaoyan Chen, Wenlong Cai,   Lingling Chai, Huanwen Xu, Lin Jia, Zhiyu Feng, Zihao Wang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Weilong Guo ,   Zhongfu Ni, Qixin Sun. (2020) A Single Amino Acid Substitution in   STKc_GSK3 Kinase Conferring Semispherical Grains and Its Implications for the Origin of Triticum sphaerococcum , The Plant Cell, 133(6):1825–1838.

20. Zhaoyan Chen, Xuejiao Cheng, Lingling Chai, Zihao Wang, Dejie Du, Zhihui Wang, Ruolin Bian, Aiju Zhao, Mingming Xin, Weilong Guo,   Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni . (2020)   Pleiotropic QTL influencing spikelet number and heading date in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 133(6):1825–1838.

19.   Linghong Li, Zhongqi Qi, Lingling Chai, Zhaoyan Chen, Tianya Wang,   Mingyi Zhang, Mingshan You, Huiru Peng, Yingyin Yao, Zhaorong Hu, Mingming Xin, Weilong Guo, Qixin Sun, Zhongfu Ni . (2020) The semidominant mutation w5 impairs epicuticular wax deposition in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 133(4):1213–1225.

18. Zhaoyan Chen, Xuejiao Cheng, Lingling Chai, Zhihui Wang, Ruolin Bian, Jiang Li, Aiju Zhao, Mingming Xin, Weilong Guo,   Zhaorong Hu, Huiru Peng, Yingyin Yao, Qixin Sun, Zhongfu Ni. (2019)   Dissection of genetic factors underlying grain size and fine mapping of QTgw.cau‐7D in common wheat (Triticum aestivum L.), Theoretical and Applied Genetics, pp 1–14.

17.   Kaiye Liu, Jie Cao, Kuohai Yu, Xinye Liu, Yujiao Gao, Qian Chen,  Wenjia  Zhang, Huiru Peng, Jinkun Du, Mingming Xin, Zhaorong Hu, Weilong Guo, Vincenzo Rossi, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2019) Wheat TaSPL8 Modulates Leaf Angle Through Auxin and Brassinosteroid Signaling, Plant Physiology, pp.00248.2019.

16. Ning Zhang, Jing Xu, Xinye Liu, Wenxing Liang, Mingming Xin, Jinkun Du, Zhaorong Hu, Huiru Peng, Weilong Guo, Zhongfu Ni, Qixin Sun, Yingyin Yao. (2019) Identification of HSP90C as a substrate of E3 ligase TaSAP5 through ubiquitylome profiling, Plant Science, 287, 110170.

15.   Panfeng Guan, Na Di, Qing Mu, Xueyi Shen, Yongfa Wang, Xiaobo Wang,   Kuohai Yu, Wanjun Song, Yongming Chen, Mingming Xin, Zhaorong Hu, Weilong Guo,   Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng. (2019) Use of   near-isogenic lines to precisely map and validate a major QTL for grain   weight on chromosome 4AL in bread wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 132, 2367–2379.

14. Peng Wu, Yan Gao, Weilong Guo, Ping Zhu. (2019) Using Local Alignment to Enhance Single Cell Bisulfite Sequencing Data Efficiency, Bioinformatics, 35(18):3273–3278.

[Software] scBS-map, https://github.com/wupengomics/scBS-map

13. Haichuan Zhu, Liuzhen Zhang, Yilin Wu, Bingjie Dong, Weilong Guo,  Mei Wang, Lu Yang, Xiaoying Fan, Yuliang Tang, Ningshu Liu, Xiaoguang Lei, Hong Wu. (2018) T-ALL leukemia stem cell 'stemness' is   epigenetically controlled by the master regulator SPI1, eLife, 7:e38314.

12. Lingling Chai, Zhaoyan Chen, Ruolin Bian, Huijie Zhai, Xuejiao Cheng, Huiru Peng, Yingyin Yao, Zhaorong Hu, Mingming Xin, Weilong Guo, Qixin Sun, Aiju Zhao, Zhongfu Ni. (2018) Dissection of two  quantitative  trait loci with pleiotropic effects on plant height and  spike length  linked in coupling phase on the short arm of chromosome 2D  of common  wheat (Triticum aestivum L.), Theoretical and Applied Genetics, 131(12):2621–2637.

11. Yongkang Zou, Zhi Qi, Weilong Guo, Liuzhen Zhang, Marcus Ruscetti, Tanu Shenoy, Ningshu Liu, Hong Wu.  (2018) Cotargeting the Cell-Intrinsic and Microenvironment Pathways of   Prostate Cancer by PI3Kα/β/δ Inhibitor BAY1082439, Molecular Cancer Therapeutics, 17(10):2091-2099.

★10. Weilong Guo*#,   Ping Zhu*, Matteo Pellegrini, Michael Zhang, Xiangfeng Wang, Zhongfu Ni. (2018) CGmapTools improves the precision of heterozygous SNV calls   and supports allele-specific methylation detection and visualization in   bisulfite-sequencing data, Bioinformatics, 34:381–387.

(# corresponding author; * Joint First Authors)

[Software] CGmapTools, https://cgmaptools.github.io

09.   Shenoy TR, Boysen G, Wang MY, Xu QZ, Guo W, Koh FM, Wang C, Zhang LZ,   Wang Y, Gil V, et al., Aziz S, Christova R, Rodrigues DN, Crespo M, Rescigno P, Tunariu N, Riisnaes R, Zafeiriou Z, Flohr P, Yuan W, Knight   E, Swain A, Ramalho-Santos M, Xu DY, de Bono J, Wu H. (2017) CHD1 loss   sensitizes prostate cancer to DNA damaging therapy by promoting   error-prone double-strand break repair, Annals of Oncology, April.

★08. Weilong Guo#,   Michael Zhang, Hong Wu#. (2016) Mammalian non-CG methylations are   conserved and cell-type specific and may have been involved in the evolution of transposon elements, Scientific Reports, 6:32207.

(# corresponding authors)

07. Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew   Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco   Morselli, Luz Orozco, Weilong Guo,   Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. (2016) Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders, EBioMedicine, May(7):157-66.

06. Marcus Ruscetti, Eman L. Dadashian, Weilong Guo,   Bill Quach, David J. Mulholland, Juw W. Park, Linh M. Tran, Naoko   Kobayashi, Daniella Bianchi-Frias, Peter S. Nelson, Yi Xing, and Hong   Wu. (2015) HDAC Inhibition Impedes HMGA2-controlled   Epithelial-Mesenchymal Plasticity and Suppresses Metastatic,   Castration-Resistant Prostate Cancer, Oncogene, (August),1-15.

05. Luz D Orozco, Marco Morselli, Liudmilla Rubbi, Weilong Guo,   James Go, Huwenbo Shi, David Lopez, Nicholas A Furlotte, Brian J   Bennett, Charles R Farber, Anatole Ghazalpour, Michael Q. Zhang, Renata   Bahous, Rima Rozen, Aldons J Lusis, Matteo Pellegrini. (2015)   Epigenome-wide association of liver methylation patterns and complex   metabolic traits in mice, Cell Metabolism, 21(6):905-917.

04. Yun Li, Jason A. Chen, Renee L. Sears, Fuying Gao, Eric D. Klein, Anna Karydas, Michael D. Geschwind, Howard J. Rosen, Adam L. Boxer, Weilong Guo,   Matteo Pellegrini, Steve Horvath, Bruce L. Miller, Daniel H. Geschwind, Giovanni Coppol. (2014) An Epigenetic Signature in Peripheral Blood  Associated with the Haplotype on 17q21.31, a Risk Factor for Neurodegenerative Tauopathy, PLoS Genetics, 10(3).

★03. Weilong Guo, Wen-Yu Chung, Minping Qian, Matteo Pellegrini, Michael Q. Zhang. (2014)  Characterizing the strand-specific distribution of non-CpG methylation in human pluripotent cells, Nucleic Acids Research, 42(5): 3009-3016.

★02. Weilong Guo,   Petko Fiziev, Weihong Yan, Shawn Cokus, Xueguang Sun, Michael Q. Zhang, Pao-Yang Chen, Matteo Pellegrini. (2013) BS-Seeker2: a versatile   aligning pipeline for bisulfite sequencing data. BMC Genomics, 14(1), 774.

[Software] BS-Seeker2, http://pellegrini.mcdb.ucla.edu/BS_Seeker2/

01. Ruijuan Li, Weilong Guo, Jin Gu, Michael Q. Zhang, Xiaowo Wang. (2012) Chromatin state and   microRNA determine different gene expression dynamics responsive to TNF stimulation, Genomics, 100(5):297-302.

中文期刊论文：

★02. 杨正钊,王梓豪,胡兆荣,辛明明,姚颖垠,彭惠茹,尤明山,宿振起#,郭伟龙#.(2020). 小麦主栽品种济麦22与良星99的基因组序列多态性比较分析. 作物学报 46(12):1870-1883.

（#共同通信作者）

01.寇小霞,张丽媛,赵月,田雪军,郭伟龙,辛明明,彭惠茹.(2018). 拟南芥翻译起始因子eIF5B-1调控种子萌发的分子机制. 中国农业大学学报23(01): 12-18.

中国人工智能学会 生物信息与人工生命专业委员会委员（2019-2024）。

中国自动化学会 智能健康与生物信息专业委员会（2020-2025）。

Nature Communications, The Plant Cell, Nucleic Acids Research, Molecular Plant, Plant Biotechnology Journal, Science Bullentin, BMC Biology, Plant Communications, Cell Reports, Genomics Proteomics & Bioinformatics, Journal of Genetics and Genomics, GigaScience, Journal of Integrative Agricultural, Crop Journal, Genome Biology and Evolution, Scientific Report, Molecular Breeding, Frontiers in Plant Science, BMC Biology, BMC Genomics, BMC Bioinformatics, iMeta, Scientific Data, PLoS One, Plants, Agronomy, Quantitative Biology, Current Bioinformatics等杂志审稿人。

小麦基因组学与智慧育种