营养与健康系（营养与健康研究院）

研究领域

化学与生物学交叉研究

1. 生物复合共轭聚合物荧光新材料

2. 分子探针与疾病早期诊断

3. 分子功能材料与营养健康

4. 食品安全与阻控技术

2023

1. Antibacterial and antioxidative biogenic films for room-temperature strawberry preservation, Liangyu Chang, Liju Xu, Zhiwen Yang, Libing Liu, Dong Qiu*, Food Chem. 2023, 405, 134893.

2. In Vitro Binding Effects of the Ecdysone Receptor-Binding Domain and PonA in Plutella xylostella, Yanjiao Feng, Jialin Cui, Binyan Jin, Xiuzhen Li, Xiaoming Zhang, Libing Liu* and Li Zhang*, Molecules 2023, 28, 1426.

3. Photoactive Conjugated Polymer-Based Strategy for Effective Inactivation of RNA Viruses, Ruilian Qi, Fengting Lv,* Yue Zeng, Qi Shen, Yiming Huang, Haotian Bai, Libing Liu and Shu Wang*, NPG Asia Materials 2023,15,17.

4. Sensitive detection of single nucleotide polymorphisms by conjugated polymers for personalized treatment of hypertension, Qi Shen, Honghong Zhang, Yiming Huang, Mingyu Li, Hao Zhao, Zhiwen Yang, Haijing Zhao, Qi Liu, Zihao Fu, Yufei Di, Libing Liu, Haotian Bai, Fengting Lv*, Yundai Chen*, Yuqi Liu*, Shu Wang*, Science Translational Medicine, 2023, 15, eabq5753.

5. Fullerene-based nanocomplex assists pulmonary delivery of siRNA for treating metastatic lung cancer, Shuai Liu, Xiangyu Sun, Huan Lu, Daiqin Chen, Xue Li, Lei Li, Shenge Su, Zhongpu Zhao, Xinran Cao, Libing Liu, Luhua Lai, Xueguang Lu, Chunying Shu, Chunru Wang *, Chunli Bai *, Nano Today, 2023, 50, 101878.

6. Ethylene resistance control technology and its application in the regulation of fruit and vegetable preservation. Yixuan Dong, Yuxuan Ding, Yihe Sun, Huan Lu, Min Ma, Jiaying Liu, Libing Liu, Food Nutrition Chemistry, 1(1), 19. https://doi.org/10.18686/fnc.v1i1.13

7. Advances in biomimetic hydrogels for organoid culture, Lili Luo, Libing Liu*, Yuxuan Ding, Yixuan Dong, Min Ma ,Chem. Comm. 2023, 59, 9675-9686. DOI: 10.1039/D3CC01274C.

2022

1. 共轭聚合物生物电子体系研究进展, 刘礼兵, 周鑫, 白昊天, 黄一鸣, 吕凤婷, 王树, 中国科学: 化学, 2022, 52, 241-249. （庆祝朱道本院士80华诞专刊）

2. Intracellular ROS-triggered Assembly of Artificial Enzyme for Initiating Catalytic Activity and Selective Imaging of Cancer Cells, Yufei Di, Endong Zhang, Zhiwen Yang, Qi Shen, Xuancheng Fu, Gang Song, Chuanwei Zhu, Haotian Bai, Yiming Huang,* Fengting Lv, Libing Liu, and Shu Wang*, Angew. Chem. Int. Ed. 2022, 61, e202116457.

3. 3D Printing of Artificial Skin Patches with Bioactive and Optically Active Polymer Materials for Anti-Infection and Augmenting Wound Repair, Hao Zhao, Jingwen Xu, Haitao Yuan, Endong Zhang, Nan Dai, Zhiqiang Gao, Yiming Huang, Fengting Lv,Libing Liu, Qi Gu,* and Shu Wang*, Mater. Horiz. 2022, 9, 342-349.

4. Nature-Inspired Nanothylakoids for Multimodal Cancer Therapeutics, Hao Zhao, Yuduo Guo, Anran Yuan, Shengpeng Xia, Zhiqiang Gao, Yiming Huang,* Fengting Lv,* Libing Liu and Shu Wang*, Sci. China Mater. 2022, 65 (7) , 1971-1979.

5. Bacteria-Mediated Intracellular Click Reaction for Drug Enrichment and Selective Apoptosis of Drug-Resistant Tumor Cells, Gao, Zhiqiang; Zhang, Endong; Zhao, Hao; Xia, Shengpeng; Bai, Haotian; Huang, Yiming*; Lv, Fengting; Liu, Libing; Wang, Shu*, ACS Appl. Mater. Interfaces 2022, 14 (10), 12106-12115.

6. Conjugated polymer materials for detection and discrimination of pathogenic microorganisms: Guarantee of biosafety, Fengyan Wang, Min Ma, Huanzhang Cao, Xingxuan Chai, Ming Huang, Libing Liu*, Biosaf. Health. 2022, 4, 79-86.

7. A hybrid nano-assembly with synergistically promoting photothermal and catalytic radical activity for antibacterial therapy, Yunxia Wang, Chuangxin Zhang, Hui Zhang, Liheng Feng*, Libing Liu*, Chin. Chem. Lett. 2022, 33, 4605-4609.

2021

1. Electrochemical regulation of antibacterial activity using ferrocene-containing antibiotics, Song Shen, Yiming Huang, Anran Yuan, Fengting Lv, Libing, Liu, Shu Wang*, CCS Chem.2021, 3, 129-135.

2. Living bacteria-mediated aerobic photo-induced radical polymerization for in-situ bacterial encapsulation and differentiation, Huan Lu, Yiming Huang*, Fengting Lv, Libing Liu, Yuguo Ma*, Shu Wang*, CCS Chem.2021, 3, 1296-1305.

3. Oligo(p-Phenylenevinylene)-Rhodium Complex as Intracellular Catalyst for Enhancing Biosynthesis of Polyhydroxybutyrate Biomaterials, Nan Dai, Hao Zhao, Wen Yu, Fengting Lv, Libing Liu*, Shu Wang*, Sci. China Chem. 2021, 64, 143-150.

4. In-Situ Synthesis of Photoactive Polymers on Living Cell Surface via Bio-Palladium Catalysis for Modulating Biological Functions, Ruilian Qi, Hao Zhao, Xin Zhou, Jian Liu, Nan Dai, Yue Zeng, Endong Zhang, Fengting Lv,* Yiming Huang, Libing Liu, Yilin Wang,* and Shu Wang*, Angew. Chem. Int. Ed.2021, 60, 5759-5765.

5. Near-Infrared Light Remote-Controlled Activation of Cancer Immunotherapy Using Photothermal Conjugated Polymer Nanoparticles, Xuancheng Fu, Yiming Huang, Hao Zhao, Endong Zhang, Qi Shen, Yufei Di, Fengting Lv, Libing Liu, and Shu Wang,* Adv. Mater.2021, 33, 2102570.

6. Biomimetic 4D-Printed Breathing Hydrogel Actuators by Nanothylakoid and Thermoresponsive Polymer Networks, Hao Zhao, Yiming Huang, Fengting Lv, Libing Liu, Qi Gu* and Shu Wang*, Adv. Funct. Mater.2021, 2105544.

7. Intracellular Radical Polymerization of Paclitaxel-Bearing Acrylamide for Self-Inflicted Apoptosis of Cancer Cells, Qi Shen, Yiming Huang,* Yue Zeng, Endong Zhang, Fengting Lv, Libing Liu, and Shu Wang*, ACS Materials Lett.2021, 3, 1307-1314.

8. Photoactive Conjugated Polymer-based Hybrid Biosystems for Enhancing Cyanobacterial Photosynthesis and Regulating Redox State of Protein, Yue Zeng, Xin Zhou, Ruilian Qi, Nan Dai, Xuancheng Fu, Hao Zhao, Ke Peng, Haitao Yuan, Yiming Huang, Fengting Lv, Libing Liu, Shu Wang*,Adv. Funct. Mater.2021, 31, 2007814.

9. Clickable amino acid derivative tuned self-assembly of antigen and adjuvant for cancer immunotherapy, Xiao He, Lan Yang, Hang Su, Shan Lin, Dongmei Qi, Hui Chen*, Yunfei Qu*, Libing Liu*, Xuli Feng*, J. Control. Release, 2021, 337, 306-316.

10. Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduction to CO in living cells for hypoxia tumor treatment, Endong Zhang, Zicheng Zuo, Wen Yu, Hao Zhao, Shengpeng Xia, Yiming Huang, Fengting Lv, Libing Liu, Yuliang Li*, Shu Wang*, Mater. Chem. Front.2021, 5, 5841-5845.

11. Photo-controlled RAFT polymerization catalyzed by conjugated polymer under aerobic aqueous conditions, Huan Lu, Yiming Huang,* Endong Zhang, Yiming Liu, Fengting Lv, Libing Liu, Yuguo Ma,* Shu Wang, ACS Macro Lett.2021, 10, 996-1001.

12. Supramolecular Regulation of Catalytic Activity for an Amphiphilic Pyrene-Ruthenium Complex in Water, Nan Dai, Ruilian Qi, Hao Zhao, Libing Liu, Fengting Lv,* Shu Wang,Chem. Eur. J. 2021, 27, 11567-11573.

13. Selective reaction of conjugated polymers with basic proteins for broad-spectrum anti-virulence therapy, Han Sun, Jing Liu, Fengting Lv, Libing Liu, Qi Gu, Baoyang Hu*, Shu Wang*, NPG Asia Materials, 2021, 13, 21.

14. 3D Bioprinting of Polythiophene Materials for Promoting Stem Cell Proliferation in Nutritionally Deficient Environment, Hao Zhao, Jingwen Xu, Endong Zhang, Ruilian Qi, Yiming Huang, Fengting Lv, Libing Liu, Qi Gu* and Shu Wang*, ACS Appl. Mater. Interfaces, 2021, 13, 25759-25770.

15. 3D Bioprinting of Reinforced Vessels by Dual-Crosslinked Biocompatible Hydrogels, Ke Peng, Xin Liu, Hao Zhao, Huan Lu, Fengting Lv, Libing Liu, Yiming Huang,* Shu Wang,* Qi Gu,* ACS Applied Bio Materials, 2021, 4, 4549-4556.

16. Sensitive Detection and Conjoint Analysis of Promoter Methylation by Conjugated Polymers for Differential Diagnosis and Prognosis of Glioma, Lixin Ma, Yiming Huang,* Hongwei Zhang,* Weihai Ning, Ruilian Qi, Haitao Yuan, Fengting Lv, Libing Liu, Chunjiang Yu,* and Shu Wang* ACS Appl. Mater. Interfaces 2021, 13, 9291-9299.

17. Polymer nanoparticles regulate macrophage repolarization for antitumor treatment, Xuancheng Fu, Jiamu Yu, Anran Yuan, Libing Liu*, Hao Zhao, Yiming Huang, Song Shen, Fengting Lv and Shu Wang, Chem. Commun., 2021, 57, 6919

18. Oral delivery of antioxidant enzymes for effective treatment of inflammatory disease, Zhiying Zeng, Xiao He, Changying Li, Shan Lin, Hui Chen*, Libing Liu*, Xuli Feng*, Biomaterials, 2021, 271 120753.

19. Nucleic acids analysis, Yongxi Zhao, Xiaolei Zuo, Qian Li, Feng Chen, Yan-Ru Chen, Jinqi Deng, Da Han, Changlong Hao, Fujian Huang, Yanyi Huang, Guoliang Ke, Hua Kuang, Fan Li, Jiang Li, Min Li, Na Li, Zhenyu Lin, Dingbin Liu, Juewen Liu, Libing Liu, Xiaoguo Liu, Chunhua Lu, Fang Luo, Xiuhai Mao, Jiashu Sun, Bo Tang, Fei Wang, Jianbin Wang, Lihua Wang, Shu Wang, Lingling Wu, Zai-Sheng Wu, Fan Xia, Chuanlai Xu, Yang Yang, Bi-Feng Yuan, Quan Yuan, Chao Zhang, Zhi Zhu, Chaoyong Yang*, Xiao-Bing Zhang*, Huanghao Yang*, Weihong Tan*, Chunhai Fan*,Sci. China Chem., 2021, 64: 171-203.

2020

1.Xin Zhou, Yue Zeng, Yongyan Tang, Yiming Huang, Fengting Lv, Libing Liu, Shu Wang*, Artificial regulation of state transition for augmenting plant photosynthesis using synthetic light-harvesting polymer materials, Sci. Adv., 2020, 6, eabc5237.

2.Panpan Gai, Wen Yu, Hao Zhao, Ruilian Qi, Feng Li,* Libing Liu, Fengting Lv, Shu Wang,* Solar-powered organic semiconductor-bacteria biohybrids for co2 reduction into acetic acid, Angew. Chem. Int. Ed.2020, 59, 7224-7229.

3.Hao Zhao, Jingwen Xu, Ke Peng, Xuancheng Fu, Endong Zhang, Fengting Lv, * Libing Liu, Na Zhang, Yilin Wang, Shu Wang* and Qi Gu*,Supramolecular nanofibers for encapsulation and in situ differentiation of neural stem cells，Adv. Healthcare Mater.2020, 9, 1901295

4.Dai, Nan; Zhao, Hao; Qi, Ruilian; Chen, Yanyan; Lv, Fengting; Liu, Libing; Wang, Shu*, Fluorescent and biocompatible ruthenium-coordinated oligo(p-phenylenevinylene) nanocatalysts for transfer hydrogenation in the mitochondria of living cells, Chem. Eur. J.2020, 26, 4489-4495.

5.Ruilian Qi, Hao Zhao, Xin Zhou, Jian Liu, Nan Dai, Yue Zeng, Endong Zhang, Fengting Lv,* Yiming Huang, Libing Liu, Yilin Wang,* and Shu Wang*, In-situ synthesis of photoactive polymers on living cell surface via bio-palladium catalysis for modulating biological functions, Angew. Chem. Int. Ed.2020, DOI: 10.1002/anie.202015247.

6.Haitao Yuan, Hao Zhao, Ke Peng, Ruilian Qi, Haotian Bai, Pengbo Zhang, Yiming Huang,* Fengting Lv, Libing Liu, Jianchun Bao,* and Shu Wang,* Conjugated polymer-quantum dot hybrid materials for pathogen discrimination and disinfection, ACS Appl. Mater. Interfaces, 2020, 12, 21263–21269.

7.Yuduo Guo, Ronghua Liu, Lingyun Zhou, Hao Zhao, Fengting Lv, Libing Liu, Yiming Huang*, Hong-Wei Zhang*, Chunjiang Yu*, Shu Wang*,Blood-brain-barrier penetrable thiolated paclitaxel-oligo (p-phenylene vinylene) nanomedicine with increased drug efficiency for glioblastoma treatment, Nano Today, 2020, 35, 100969.

8.Xin Zhou, Fengting Lv,* Yiming Huang, Libing Liu, and Shu Wang,* Biohybrid conjugated polymer materials for augmenting energy conversion of bioelectrochemical systems, Chem. Eur. J.2020, 26, 15065-15073.

9.Huan Lu, Xinpeng Jiang, Yanyan Chen, Ke Peng, Yiming Huang, Hao Zhao, Qi Chen, Fengting Lv,* Libing Liu, Shu Wang* Yuguo Ma*, Cyclometalated iridium(iii) complex nanoparticles for mitochondria-targeted photodynamic therapy, Nanoscale, 2020, 12, 14061-14067.

10.Xuancheng Fu, Jiamu Yu, Nan Dai, Yiming Huang, Fengting Lv*, Libing Liu, and Shu Wang,Optical Tuning of Antibacterial Activity of Photoresponsive Antibiotics, ACS Appl. Bio Mater.2020, 3, 4751-4755.

11.Ke Peng, Fengting Lv*, Huan Lu, Jianwu Wang, Hao Zhao, Libing Liu, Shu Wang, Conjugated polymer nanoparticles as fluorescence switch for selective cell imaging, Chin. Chem. Lett.2020, 31, 755-758.

12.Ke Peng, Shanshan Liu, Fengting Lv*, Xuancheng Fu, Sameer Hussain, Hao Zhao, Libing Liu, and Shu Wang, Wireless charging electrochemiluminescence system for ionic channel manipulation in living cells, ACS Appl. Mater. Interfaces 2020, 12, 24655-24661.

13.Sameer Hussain, Fengting Lv,* Ruilian Qi, Thangaraj Senthilkumar, Hao Zhao, Yanyan Chen, Libing Liu, Shu Wang, Förster resonance energy transfer mediated rapid and synergistic discrimination of bacteria over fungi using a cationic conjugated glycopolymer, ACS Appl. Bio Mater.2020, 3, 20-28.

14.Zhang, Pengbo; Xu, Chunling; Zhou, Xin; Qi, Ruilian; Liu, Libing; Lv, Fengting; Li, Zhengping*; Wang, Shu*, Cationic conjugated polymers for enhancing beneficial bacteria adhesion and biofilm formation in gut microbiota, Colloids and Sur. B, Biointerfaces2020, 188, 110815.

15.Pengbo Zhang, Tian Qiu, Libing Liu, Fengting Lv, Zhengping Li,* Jianming Ying,* Shu Wang,* Conjoint analysis of dna methylation for tumor differentiation using cationic conjugated polymers, ACS Appl. Bio Mater.2020, 3, 2867-2872.

16.Fu, Xuancheng; Bai, Haotian; Lyu, Fengting; Liu, Libing; Wang, Shu*, Conjugated polymer nanomaterials for phototherapy of cancer, Chem. Res. Chinese Universities2020, 36, 237-242.

17.Syeda Sadia Khatoon, Yanyan Chen, Hao Zhao, Fengting Lv, Libing Liu,* Shu Wang,* In situ self-assembly of conjugated polyelectrolytes for cancer targeted imaging and photodynamic therapy, Biomater. Sci.2020, 8, 2156-2163.

18.Xin Zhou, Fengting Lv, Libing Liu, Yiming Huang, and Shu Wang*,Bacteriorhodopsin-based biophotovoltaic devices driven by chemiluminescence as endogenous light source, Adv. Optical Mater.2020, 8, 1901551.

19.Yuqi Liu, Liuyang Tian, Yang Li, Yanyan Chen, Yundai Chen,* Libing Liu,* Shu Wang, Photoactive oligo(p-phenylene vinylene) material for functional regulation of induced pluripotent stem cells, ACS Appl. Mater. Interfaces,2020, 12, 3438-3444.

20.Jiang, Linye; Liu, Libing; Lv, Fengting; Wang, Shu*; Ren, Xueqin*,Integration of self-luminescence and oxygen self-supply: a potential photodynamic therapy strategy for deep tumor treatment, ChemPlusChem 2020, 85, 510-518.

21.Shanshan Wang, Pradeepkumar Jagadesan, Han Sun, Rong Hu, Zhiliang Li, Yun Huang, Libing Liu, Shu Wang, Muhammad Younus, Kirk S. Schanze*, Fluorescence imaging of mammalian cells with cationic conjugated polyelectrolytes, ChemPhotoChem2020, DOI: 10.1002/cptc.202000192.

22.Qingling Xu, Fengting Lv, Libing Liu, and Shu Wang*, Development of a thermo-responsive conjugated polymer with photobleaching-resistance property and tunable photosensitizing performance, Macromol. Rapid Commun.2020, 2000249.

2019

1.In situ-induced multivalent anticancer drug clusters in cancer cells for enhancing drug efficacy, Lingyun Zhou, Fengting Lv*, Libing Liu, Shu Wang, CCS Chem. 2019, 1, 97-105.

2.Conducting Polymers-Thylakoid Hybrid Materials for Water Oxidation and Photoelectric Conversion, Xin Zhou, Lingyun Zhou, Pengbo Zhang, Fengting Lv,* Libing Liu, Ruilian Qi, Yilin Wang, Mo-Yuan Shen, Hsiao-hua Yu,* Guillermo Bazan* and Shu Wang*, Adv. Electron. Mater. 2019, 5(3), 1800789.

3.Conductive Polymer-Exoelectrogen Hybrid Bioelectrode with Improved Biofilm Formation and Extracellular Electron Transport, Pengbo Zhang, Xin Zhou, Ruilian Qi, Panpan Gai, Libing Liu, Fengting Lv and Shu Wang*, Adv. Electron. Mater. 2019, 5, 1900320.

4.Reactive Amphiphilic Conjugated Polymers for Inhibiting Amyloid β Assembly, Han Sun, Jing Liu, Shengliang Li, Lingyun Zhou, Jianwu Wang, Libing Liu,* Fengting Lv, Qi Gu,* Baoyang Hu, Yuguo Ma* and Shu Wang*, Angew. Chem. Int. Ed. 2019, 131 (18), 5988-5993.

5.Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy, Linye Jiang, Haotian Bai, Libing Liu,* Fengting Lv, Xueqin Ren* and Shu Wang*, Angew. Chem. Int. Ed. 2019, 58, 10660-10665.

6.Conjugated Polymer Enhanced Photoelectric Response of Self-Circulating Photosynthetic Bioelectrochemical Cell, Xin Zhou, Panpan Gai, Pengbo Zhang,Han Sun, Fengting Lv,* Libing Liu, and Shu Wang*, ACS Appl. Mater. Interfaces, 2019, 11, 38993-39000.

7.Design of Amphiphilic Perylene Diimide for Optical Recognition of Anticancer Drug through Chirality-Induced Helical Structure, Hao Zhao, Sameer Hussain, Xiaoyan Liu, Shengliang Li, Fengting Lv,* Libing Liu, and Shu Wang*, Chem. Eur. J. 2019, 25, 9834-9839.

8.Supramolecular Nanofibers for Encapsulation and in situ Differentiation of Neural Stem Cells，Hao Zhao, Jingwen Xu, Ke Peng, Xuancheng Fu, Endong Zhang, Fengting Lv, * Libing Liu, Na Zhang, Yilin Wang, Shu Wang* and Qi Gu*, Adv. Healthcare Mater. 2019, 1901295.

9.Reactive Conjugated Polymers for Modulation of Islet Amyloid Polypeptide Assembly, Han Sun, Fengting Lv, Libing Liu,* and Shu Wang*, ACS Appl. Mater. Interfaces, 2019, 11, 22973-22978.

10.Boronic Acid-Functionalized Conjugated Polymer for Controllable Cell Membrane Imaging, Hao Zhao, Ke Peng, Fengting Lv, Libing Liu, Shu Wang*, ACS Appl. Bio Mater. 2019, 2, 1787-1791.

11.Antimicrobial activity of a conjugated polymer with cationic backbone, Qingling Xu, Ping He, Jianwu Wang, Hui Chen, Fengting Lv, Libing Liu, Shu Wang*, Juyoung Yoon*, Dyes and Pigments, 2019, 160, 519-523.

12.Designing an Amino-Fullerene Derivative C70−(EDA)8 to Fight Superbacteria, Junfang Zhang, Jiachao Xu, Haijun Ma, Haotian Bai, Libing Liu, Chunying Shu, Hui Li,* Shu Wang,* Chunru Wang*, ACS Appl. Mater. Interfaces 2019, 11, 14597−14607.

13.Water-Soluble Conjugated Organic Molecules as Optical/Electrochemical Materials for Interdisciplinary Biological Applications, Lingyun Zhou, Fengting Lv*, Libing Liu, Shu Wang*, Acc. Chem. Res. 2019, 52, 11, 3211-3222.

14.An Optoelectronic Device for Rapid Monitoring of Creatine Kinase Using Cationic Conjugated Polyelectrolyte, Sameer Hussain, Hao Zhao, Lingyun Zhou, Xin Zhou, Parameswar Krishnan Iyer*, Fengting Lv, Libing Liu, Shu Wang*, Adv. Mater. Technol. 2019, 4, 1900361

15.Bacteriorhodopsin-Based Biophotovoltaic Devices Driven by Chemiluminescence as Endogenous Light Source, Xin Zhou, Fengting Lv, Libing Liu, Yiming Huang, and Shu Wang*, Adv. Optical Mater. 2019, 1901551.

16.Optically-controlled supramolecular self-assembly of an antibiotic for antibacterial regulation, Xuancheng Fu, Haotian Bai, Ruilian Qi, Hao Zhao, Ke Peng, Fengting Lv, Libing Liu* and Shu Wang*, Chem. Commun., 2019, 55, 14466–14469.

出版专著：

核酸纳米技术，科学出版社，2021

功能有机共轭分子体系的生物应用基础，科学出版社，2020

纳米生物材料，化学工业出版社，2018

Artificial Riboswitches: Methods and Protocols，HumanaPressInc，2014

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