金危危

金危危，博士，教授，杰青

1989-1996年 湖南农业大学学士/硕士学位

1998-2001年 武汉大学博士学位

2002-2004年 美国威斯康辛大学博士后

2005-2006年 美国威斯康辛大学助理研究员

2006至今   中国农业大学教授

2010年    获国家杰出青年科学基金

研究方向】

1.玉米株型、育性等重要功能基因的克隆

2.玉米近缘种（薏苡、摩擦禾等）的基因组学研究

3.玉米单倍体诱导机理的研究

4.玉米等作物染色体着丝粒的结构和功能研究

【主持项目】

1.玉米骨干自交系深度重测序及有利基因大规模挖掘，国家863计划

2.作物基因组学，国家杰出青年科学基金项目

3.玉米株高基因sd7、pin1和subr2的调控网络解析，国家自然科学基金-重大研究计划集成项目

4.玉米半矮秆基因Sd7和sd8的克隆和功能分析，国家自然科学基金-重大研究计划重点项目

5.玉米温敏无雄穗基因Tvt2的克隆和功能分析，国家自然科学基金-联合基金重点项目

【研究进展】

1.玉米株型、穗发育及育性等重要基因的克隆

克隆调控玉米株型建成、成花转换和雄性不育的关键基因la1、ipe1、Sdt7、tvt1-R、dlf1等；阐明显性基因Si3引起玉米花序发育和小花性别决定紊乱的分子机制；解析hsp101和invan6介导减数分裂抗热性的重要作用(Plant Physiol 2013, 2017,2020a, 2020b; New Phytol 2020, 2022; Plant Cell 2020, 2022)。

2.玉米、薏苡基因组及进化驯化研究

完成薏苡基因组组装，为薏苡从头驯化提供基因组基础；揭示现代玉米中大片段PAV的摩擦禾来源，为玉米进化提供新的见解；解析了燕麦玉米附加系中单条玉米染色体的转录组和表观组变化，以此为模型阐释远缘杂交后异源基因组间的协调机制(Nucleic Acids Res 2018; Mol Plant 2020; Genome Biol 2021)。

3.玉米单倍体诱导机理的研究

结合细胞学、分子生物学和基因组学，证实玉米单倍体的染色体消除假说；参与玉米单倍体育种高效技术体系的创建（2016年度高等学校科学研究优秀成果技术发明奖，一等奖）；通过单细胞测序发现单倍体诱导系花粉精核片段化现象，相关研究丰富了玉米单倍体诱导机理(Plant Physiol 2013; Mol Plant 2017; Nat Commun 2017)。

【代表性论文】

1. Li YF, Huang YM, Sun HY, Wang TY, Ru W, Pan LL, Zhao XM, Dong ZB, Huang W*, Jin WW*. Heat shock protein 101 contributes to the thermotolerance of male meiosis in maize. Plant Cell 2022, 34(10):3702-3717.

2. Huang W, Li YF, Du Y, Pan LL, Huang YM, Liu HB, Zhao Y, Shi YL, Ruan YL, Dong ZB*, Jin WW*. Maize cytosolic invertase INVAN6 ensures faithful meiotic progression under heat stress. New phytol 2022, 236(6):2172-2188.

3. Huang YM, Huang W, Meng Z, Braz GT, Li YF, Wang K, Wang H, Lai JS, Jiang JM, Dong ZB*, Jin WW*. Megabase-scale presence-absence variation with Tripsacum origin was under selection during maize domestication and adaptation. Genome Biol 2021, 22(1):237.

4. Luo HS, Meng DX, Liu HB, Xie MJ, Yin CF, Liu F, Dong ZB, Jin WW*. Ectopic expression of the transcriptional regulator silky3 causes pleiotropic meristem and sex determination defects in maize inflorescences. Plant Cell 2020, 32, 3750-3773.

5. Xie SY, Luo HB, Huang YM, Wang YX, Ru W, Shi YL, Huang W, Wang H, Dong ZB, Jin WW*. A Missense Mutation in a Large Subunit of Ribonucleotide Reductase Confers Temperature-Gated Tassel Formation. Plant Physiol 2020, 184, 1979-1997.

6. Sun HY, Wang CL, Chen XY, Liu HB, Huang YM, Li SX, Dong ZB, Zhao XM, Tian F*, Jin WW*. dlf1 promotes floral transition by directly activating ZmMADS4 and ZmMADS67 in the maize shoot apex. New Phytol 2020, 228, 1386-1400.

7. Liu HB, Shi JP, Cai ZX, Huang YM, Lv ML, Du HL, Gao Q, Zuo Y, Dong ZB, Huang W, Qin R, Liang CZ, Lai JS*, Jin WW*. Evolution and Domestication Footprints Uncovered from the Genomes of Coix. Mol Plant 2020, 13, 295-308.

8. Li HC, Wang LJ, Liu MS, Dong ZB, Li QF, Fei SL, Xiang HT, Liu BS*, Jin WW*. Maize Plant Architecture Is Regulated by the Ethylene Biosynthetic Gene ZmACS7. Plant Physiol2020,183: 1184–1199.

9. Wang GX, He QY, Zhao H, Cai ZX, Guo N, Zong M, Han S, Liu F, Jin WW*. ChIP-cloning analysis uncovers centromere-specific retrotransposons in Brassica nigra and reveals their rapid diversification in Brassica allotetraploids. Chromosoma 2019, 128, 119-131.

10. Tian JG, Wang CL, Xia JL, Wu LS, Xu GH, Wu WH, Li D, Qin WC, Han X, Chen QY, Jin, W, Tian, F*. Teosinte ligule allele narrows plant architecture and enhances high-density maize yields. Science2019, 365, 658-664.

11. Zhang L, Luo HB, Zhao Y, Chen XY, Huang YM, Yan SS, Li SX, Liu MS, Huang W, Zhang XL, Jin WW*. Maize male sterile 33 encodes a putative glycerol-3-phosphate acyltransferase that mediates anther cuticle formation and microspore development. BMC Plant Biol 2018, 18, 318.

12. Dong ZB, Yu J, Li H, Huang W, Xu L, Zhao Y, Zhang T, Xu WY, Jiang JM, Su Z*, Jin WW*. Transcriptional and epigenetic adaptation of maize chromosomes in Oat-Maize addition lines. Nucleic Acids Res 2018,46(10): 5012-5028.

13. Meng DX, Zhao JY, Zhao C, Luo HS, Xie MJ, Liu RY, Lai JS, Zhang XL, Jin WW*. Sequential gene activation and extensive gene imprinting during early embryo development in maize. Plant J 2018, 93:445-459.

14. Li X, Meng D, Chen S, Luo H, Zhang Q, Jin W*, Yan J*. Single pollen nucleus sequencing reveals chromosome fragmentation as a possible cause of haploid induction in maize. Nat Commun 2017, 8(1):991.

15. Liu C, Li X, Meng D, Zhong Y, Chen C, Dong X, Xu X, Chen B, Li W, Li L, Tian X, Zhao H, Song W, Luo H, Zhang Q, Lai J, Jin W*, Yan J*, Chen S*. A 4bp insertion at ZmPLA1 encoding a putative phospholipase A generates haploid induction in maize. Mol Plant 2017, 10(3):520-522.

16. Chen XY, Zhang H, Sun HY, Luo HB, Zhao L, Dong ZB, Yan SS, Zhao C, Liu RY, Xu CY, Li S, Chen HB, Jin WW*. IRREGULAR POLLEN EXINE1 is a novel factor in anther cuticle and 30 pollen exine formation. Plant Physiol 2017, 173(1):307-325.

17. Huang W, Du Y, Zhao X, Jin W*. B chromosome contains active genes and impacts the transcription of A chromosomes in maize (Zea mays L.). BMC Plant Biol 2016, 16(1):88.

18. Dong Z, Jiang C, Chen X, Zhang T, Ding L, Song W, Luo H, Lai J, Liu R, Chen H, Zhang L*, Jin W*. Maize LAZY1 mediates shoot gravitropism and inflorescence development through regulating auxin transport, auxin signaling and light response.Plant Physiol2013, 163(3):1306-1322.

19. Zhao X, Xu X, Xie H, Chen S, Jin W^*. Fertilization and uniparental chromosome elimination during crosses with maize haploid inducers. Plant Physiol2013, 163(2):721-731.

20. Wang G, Li H, Cheng Z, Jin W^*. A novel translocation event leads to a recombinant stable chromosome with interrupted centromeric domains in rice. Chromosoma 2013, 122(4):295-303.

21. Du Z, Li H, Wei Q, Zhao X, Wang C, Zhu Q, Yi X, Xu W, Liu XS^*, Jin W^*, Su Z^*. Genome-Wide Analysis of Histone Modifications: H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativa L. Japonica. Mol Plant 2013, 6(5):1463-1472. 

22. Li B, Choulet F, Heng Y, Hao W, Paux E, Liu Z, Yue W, Jin W^*, Feuillet C^*, Zhang X^*. Wheat centromeric retrotransposons: the new ones take a major role in centromeric structure. Plant J 2013, 73(6):952-965.

23. Lai JS#, Li RQ#, Xu X#, Jin WW#, Xu ML#, Zhao HL, Xiang ZK, Song WB, Ying K, ...... et al. Genome-wide patterns of genetic variation among elite maize inbred lines.Nat Genet 2010, 42:1027-1030. (# 并列第一作者)

24. Han YH, Zhang ZH, Liu CX, Liu JH, Huang SW, Jiang J, Jin WW*. Centromere repositioning in cucurbit species: Implication of the genomic impact from centromere activation and inactivation. Proc Natl Acad Sci USA 2009, 106:14937-14941.

主讲课程：

研究生课程《分子细胞遗传学》

本科生课程《现代农业》

国务院学位委员会学科评议组（作物学）成员

中国种子协会副会长

中国作物学会副理事长

中国作物学会人才培养与教育专业委员会发展战略咨询委员

《作物学报》副主编

《中国农业大学学报》编委会副主任

《玉米科学》编委

《Chromosome Research》编委

《The Crop Journal》编委

《Reproduction and Breeding》编委

华北作物改良与调控国家重点实验室学术委员会委员

农业部甘薯生物学与生物技术重点实验室学术委员会委员

教育部作物基因资源与遗传改良国际合作联合实验室学术委员会委员

国家现代农业与食品前沿产业技术创新联盟指导委员会委员

本科生课程：近十年课程数据
研究生课程：近十年课程数据

软件著作 专利