于舒洋

于舒洋：中国农业大学生物学院教授、博士生导师。先后在瑞典Karolinska Institute，美国Vanderbilt University和University of Iowa从事博士后研究工作。主要从事造血干细胞（HSC）和T细胞发育分化及功能的研究。独立后获得国家自然基金委“优青”资助，主持“干细胞重点研发专项”子课题和国家自然科学基金“重点”和“面上”项目。目前科研兴趣为RNA结合蛋白在造血干细胞的维系与发育中的功能和分子机理研究，T细胞分化发育和感染后应答过程中的转录水平和RNA结合蛋白介导的转录后水平的调控机制。迄今，发表SCI论文40余篇，第一作者(含并列第一)、通讯(含并列通讯)作者文章26篇，其中包括，包括Nature Immunology (2014), Immunity (2012, 2010), Cell Stem cell (2012), Blood (2011，2013), Science Advances (2021), Nature Communication (2021), eLife (2021), CMI (2021a, 2021b), Theranostics (2021), Protein Cell (2020), FASEB J (2019a, 2019b), Front Immunol (2018), RNA Biology (2018), JBC (2010, 2016), JI (2010)和JV(2006)等领域内顶尖和权威杂志。文章累计被引次数1200余次。未来工作将聚焦于HSC谱系分化和T淋巴细胞发育和应答研究，力争为相关领域的基础理论发展和临床血液病的诊疗做出贡献。

• 参与本科生教学：

遗传学

• 参与研究生教学：

动物科学seminar

分子免疫学专题

• 农业生物技术学会理事。

• 生物化学与分子生物学会青年委员。

• 多个学术期刊的特邀审稿人。

研究方向：

1、围绕着HSC和血液系统中具有重要功能的成熟细胞亚群的分化发育：

• 利用多种基因修饰小鼠模型分析重要的功能基因和信号通路对HSC自我更新和分化发育的分子机制；

• 转录因子及RNA结合蛋白在T细胞、B细胞、NK细胞等淋巴细胞中的功能和调控机理；

• GABP和TCF/LEF转录因子的互作蛋白和复合物在HSC及成熟血细胞发育分化中的调控机制；

2、利用人源化小鼠模型研究干细胞移植后免疫原性及免疫应答机制。

本科生课程：近十年课程数据

纵向项目

论文题目	刊物名称	收录类别	发表年月	第一作者或全部作者	第一作者单位	排名
Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	FASEB J	SCI	2019 Jan	Liu Juanjuan	China Agricultural University	Corresponding (16/16)
Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions.	FASEB J	SCI	2019 Feb	Cao Dengchao	China Agricultural University	Co-corresponding (20/21)
Genetic Removal of the CH1 Exon Enables the Production of Heavy Chain-Only IgG in Mice.	Front Immunol	SCI	2018 Sep	Zhang Tianyi	China Agricultural University	Co-corresponding (14/16)
Long noncoding RNA Malat1 is not essential for T cell development and response to LCMV infection.	RNA biology	SCI	2018 Nov	Yao Yinpeng	China Agricultural University	Corresponding (13/13)
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes	Cell Res	SCI	2018 Aug	Juan Chen	Institute of Biophysics, Chinese Academy of Sciences	Co-author (16/18)
Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity	J Exp Med	SCI	2018 Aug	Xing Shaojun	University of Iowa	Co-author (11/15)
Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1	Cell Stem Cell	SCI	2017 Sep	Li Fenglin	University of Iowa	Co-author (4/10)
Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice.	Science Bulletin	SCI	2017 Nov	Cui Zhengzhi	China Agricultural University	Co-corresponding (10/10)
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors	J Biol Chem	SCI	2016 May	Yu Shuyang	China Agricultural University	First and Co-corresponding (1/6)
Developing a triple transgenic cell line for high-efficiency porcine reproductive and respiratory syndrome virus infection	PLoS One	SCI	2016 May	Zhang Linlin	China Agricultural University	Co-corresponding (8/9)
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity	Nat Immunol	SCI	2016 Jun	Xing Shaojun	University of Iowa	Co-author (5/17)
Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds	J Immunol	SCI	2016 Jun	Han Binyue	China Agricultural University	Co-author (6/23)
CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections	Immunity	SCI	2016 Dec	He Bing	University of Iowa	Co-author (9/13)
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow	Nat Immunol	SCI	2015 Oct	Yang Qi	University of Iowa	Co-author (9/13)
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation	J Exp Med	SCI	2015 May	Tiffany Carr	The University of Chicago	Co-author (3/6)
TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells	Nat Immunol	SCI	2014 Jul	Farrah C Steinke	University of Iowa	Co-first (2/10)
TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes	Blood	SCI	2013 May	Yu Shuyang	China Agricultural University	First and Co-corresponding (1/2)
The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy	Immunity	SCI	2012 Oct	Yu Shuyang	University of Iowa	First (1/13)
Fidelity of a BAC-EGFP transgene in reporting dynamic expression of IL-7Rα in T cells	Transgenic Res	SCI	2012 Feb	Yu Shuyang	University of Iowa	First (1/6)
Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells	Cell Stem Cell	SCI	2012 Aug	Yu Shuyang	University of Iowa	First (1/5)
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells	Blood	SCI	2011 Feb	Yu Shuyang	University of Iowa	First (1/7)
Constitutive activation of Wnt signaling favors generation of memory CD8 T cells	J Immunol	SCI	2010 Feb	Zhao Dongmei	University of Iowa	Co-first (2/8)
Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1.Immunity	Immunity	SCI	2010 Aug	Zhou Xinyuan	University of Iowa	Co-first (2/6)
Critical requirement of GABP{alpha} for normal T cell development	J Biol Chem	SCI	2010 Apr	Yu Shuyang	University of Iowa	First (1/4)
Construction of a high efficiency PCR products cloning T vector using pGEM-5zf (+)	Avicenna J Med Biotechnol	SCI	2009 Apr	Zhao Yaofeng	Karolinska University Hospital Huddinge	Co-author (3/6)
PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis	J Neuroimmunol	SCI	2008 Jul	Ann Kari Lefvert	Karolinska University Hospital Solna	Co-author (4/6)
Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice	Immunology	SCI	2007 Jul	Lu wei	China Agricultural University	Co-author (4/9)
Construct synthetic gene encoding artificial spider dragline silk protein and its expression in milk of transgenic mice	Anim Biotechnol	SCI	2007 Feb	Xu hongtao	China Agricultural University	Co-author (3/11)
Expression of insulin-like growth factors systems in cloned cattle dead within hours after birth	Mol Reprod Dev	SCI	2006 Nov	Li Shijie	China Agricultural University	Co-author (3/8)
Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis	Proc Natl Acad Sci U S A	SCI	2006 Aug	Zhao Yaofeng	China Agricultural University	Co-author (3/8)
Maternally derived recombinant human anti-hantavirus monoclonal antibodies are transferred to mouse offspring during lactation and neutralize virus in vitro	Journal of Virology	SCI	2006 Apr	Yu Shuyang	China Agricultural University	First (1/15)
Aberrant gene expression in organs of bovine clones that die within two days after birth	Biol Reprod	SCI	2005 Feb	Li Shijie	China Agricultural University	Co-author (5/8)
Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene	Sci China C Life Sci	SCI	2005 Aug	Yu Zhengquan	China Agricultural University	Co-author (10/11)
Effects of Fucosylated Milk of Goat and Mice on H. pylori Binding to Lewis b Antigen	World J Gastroenterol	SCI	2004 Jul	Xu hongtao	China Agricultural University	Co-author (6/13)
The Cloning of Human alpha-Lactalbumin Gene and High-Level Expression in Milk of Transgenic Mice	Progress in Biochemistry and Biophysics	SCI	2004 Jan	Yu Shuyang	China Agricultural University	First (1/7)

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