张成

张成，博士，副教授。2006年毕业于山东轻工业学院应用化学专业，获工学学士学位。2009年毕业于大连理工大学应用化学专业，获工学硕士学位。2013年毕业于中国科学院大连化学物理研究所有机化学专业，获得理学博士学位。2013-2016在美国南卡罗来纳医科大学（Medical University of South Carolina，Department of Drug Discovery & Biomedical Sciences）从事博士后研究工作。2016年7月加入中国农业大学理学院应用化学系，从事科研和教学工作。

教学方面：

承担本科生基础课《有机化学B》、《有机化学实验》

主讲国际学院全英文课程《General Chemistry》

科研方面：

1、手性配体的设计和合成

2、基于硼（硅）化学的新反应研究

3、生物活性分子（医药、农药）的合成和开发

文章发表：

Publications @CAU

15)  Hao Deng#,Yujie Dong#,Yu Shangguan, Fazhou Yang, Sheng Han, Jiaqi Wu, Bo Liang, Hongchao Guo,and Cheng Zhang*. Copper-Catalyzed Three-Component Carboboronation of Allenes Using Highly Strained Cyclic Ketimines as Electrophiles. Org. Lett. 2021, 23, 4431-4435. (# These authors contributed equally to this article)

14）Fazhou Yang,Ziyan Liu,Hao Liu,Yu Shangguan,aHao Deng,Jiaxing Huang,Yumei Xiao,Hongchao Guo and Cheng Zhang*. Cu-Catalysed synthesis of benzo[f]indole-2,4,9 (3H)-triones by the reaction of 2-amino-1,4-napthoquinones with α-bromocarboxylates. Org. Biomol. Chem.,2020, 18, 6724.

13) Yu Shangguan, Fazhou Yang, Hao Deng, Hao Liu, Ziyan Liu, Wanyue Zhuang, Chenxi Qiao, Aizheng Wang, Yumei Xiao, and Cheng Zhang*. Copper-Catalyzed Three-Component Difunctionalization of Aromatic Alkenes with 2‑Amino-1,4-naphthoquinones and α‑Bromocarboxylates. J. Org. Chem.2019, 84, 10649-10657.

12) Hao Deng, Ziwei Meng, Sifan Wang, Zheming Zhang, Yaqi Zhang, Yu Shangguan, Fazhou Yang, Dekai Yuan, Hongchao Guo, and Cheng Zhang*. Enantioselective Copper-Catalyzed Three-Component Carboboronation of Allenes: Access to Functionalized Dibenzo [b,f][1,4]oxazepine Derivatives. Adv. Synth. Catal.2019, 361, 3582–3587. Very important publication (VIP) & Inside cover picture (DOI:10.1002/adsc.201900787)

11) Wei Sun, Feng Jiang, Honglei Liu, Xing Gao, HaoJia, Cheng Zhang*, Hongchao Guo*. Double [3+2] cycloaddition of nitrile oxides with allenoates: Synthesis of spirobidihydroisoxazoles. Chin. Chem. Lett. 2019, 30, 363-366.

10) Qijun Wang,^# Bo Wang,^# Hao Deng, Yu Shangguan, Yan Lin, Yaqi Zhang, Zheming Zhang, Yumei  Xiao, Hongchao Guo, and Cheng Zhang*. Silver-Catalyzed Three-Component Difunctionalization of Alkenes via Radical Pathways: Access to CF3‑Functionalized AlkylSubstituted 1,4-Naphthoquinone Derivatives. J. Org. Chem. 2019, 84, 1006−1014.

(9) Feng Jiang, Xinping Feng, Rou Wang, Xing Gao, Hao Jia, Yumei Xiao, Cheng Zhang*, Hongchao Guo*.Asymmetric [3 + 3] Annulation of Copper–Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3-c]pyrazoles. Org. Lett.2018, 20, 5278-5281.

(8) Cheng Zhang*，C. James Chou*. Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as an Amide Source: Application in the Synthesis of an HDAC6 Inhibitor. Org. Lett.2016, 18, 5512-5515.

Postdoc Publications

(7) Jesse J. McClure^#, Elizabeth S. Inks^#, Cheng Zhang^#, Yuri K. Peterson, Jiaying Li, Kalyan Chundru, Bradley Lee, Ashley Buchanan，Shiqin Miao, and C. James Chou*，Comparison of the Deacylase and Deacetylase Activity of ZincDependent HDACs，ACS Chem. Biol.2017, 12, 1644–1655.

(6) Jesse J. McClure^#，Cheng Zhang^#，Elizabeth S. Inks，Yuri K. Peterson，Jiaying Li，C. James Chou*，Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia，J. Med. Chem.2016, 59, 9942~9959.

(5) Cheng Zhang*, Jesse McClure, C. James Chou*. Silver-Catalyzed Direct Thiolation of Quinones by Activation of Aryl Disulfides to Synthesize Quinonyl Aryl Thioethers. J. Org. Chem.2015, 80, 4919-4927. (Highlighted in Cheminform, 2015, 46, DOI: 10.1002/chin.201539082).

Graduate Publications

(4) Cheng Zhang, Yun-Ze Hui, De-Yang Zhang, Xiang-Ping Hu*. Highly Diastereo-/Enantioselective Cu-catalyzed Propargylic Alkylations of Propargyl Acetates with Cyclic Enamines. RSC Adv.2016, 6, 14763-14767.

(3) Cheng Zhang, Ya-Hui Wang, Xin-Hu Hu, Zhuo Zheng, Jie Xu, Xiang-Ping Hu*. Chiral P,N,N-Ligands for Highly Enantioselective Cu-Catalyzed Propargylic Amination with Both Primary and Secondary Amines As Nucleophiles. Adv. Synth. Catal.2012, 354, 2854-2858.

(2) Cheng Zhang, Xin-Hu Hu, Ya-Hui Wang, Zhuo Zheng, Jie Xu, Xiang-Ping Hu*. Highly Diastereo- and Enantioselective Cu-Catalyzed [3+3] Cycloaddition of Propargyl Esters with Cyclic Enamines toward Chiral Bicyclo[n.3.1] Frameworks. J. Am. Chem. Soc.2012, 134, 9585-9588.(Highlighted in J. Am. Chem. Soc. 2012, 134, 11051-11052; Synfacts, 2012, 8, 0992; Chin. J. Org. Chem. 2012, 32, 1760).

(1) Cheng Zhang, Sai-Bo Yu, Xiang-Ping Hu*, Dao-Yong Wang, Zhuo Zheng*. New Chiral Ferrocenyl P,S-Ligands for Highly Diastereo-/Enantioselective Catalytic [3+2] Cycloaddition of Azomethine Ylides with Cyclic and Acyclic Enones . Org. Lett.2010, 12, 5542-5545. (Highlighted in Cheminform, 2011, 42, DOI: 10.1002/chin.201112113).

张成课题组主要围绕过渡金属催化的饱和烃、不饱和烃官能化反应开展研究工作，其中涉及过渡金属催化（新的催化体系探索）、不对称催化（手性配体的设计和合成）、自由基化学（选择性控制）、硼（硅）化学等多方面的研究内容，并期望以上述工作为基础，进行生物活性分子（医药、农药）的开发工作。