Zhengshijun

EDUCATION AND POST-GRADUATE TRAINING

2000-2005. Post-doctoral fellow,Professor Youhai H Chen. University   of PennsylvaniaSchool of Medicine. Molecular   Immunology.

2000. Ph.D.University   of MassachusettsAmherst, Professors Douglas   Freeman/ Samuel Black/Cynthia Baldwin, Immunology

1990.M.S. China Agricultural   University. Professor   Menghou Gan, Infectious Disease and Preventive Veterinary Medicine.

1987. D.V.M. China Agricultural UniversityCollege   of Veterinary Medicine.

FACULTY APPOINTMENTS

2005-present, Professor   of Microbiology and Immunology, Department   of Preventive Veterinary Medicine, College     of Veterinary Medicine, China   Agricultural University

2010-2015,Associate Dean of College of Veterinary Medicine

1993-1996,Senior Lecturer of   Immunology, Department of   Preventive Veterinary Medicine,    China   Agricultural University

1990-1993,Lecturer of Immunology,China Agricultural   University. Veterinary Microbiology and Immunology.

Editorial Board Member

2013-present, Editor-in-Chief for the journal Asian Case   Reports in Veterinary Medicine

2014-present, Editorial board memberfor thejournal Frontier in Agri and Engineering

2012-Present, Reviewer editorial board member for   the journal Frontier in Microbiology

PUBLICATIONS-papers

1.Wang B, FuM, Liu Y, WangY, LiX, Cao H, and Zheng SJ^*gga-miR-155   Enhances Type I Interferon Expression and Suppresses Infectious Burse Disease   Virus Replication via Targeting SOCS1 and TANK.Frontier in Cellular and   Infection Microbiology 2018, March 7, 8(55); 1-13, doi: 10.3389/fcimb.2018.00055

2.Chen   X, He Z, FuM, WangY, Wu H, LiX, Cao H, and Zheng SJ ^*The E3 ubiquitin ligase Siah-1 suppresses   avian reovirus infection by targeting p10 for degradation, J   Virology 2018 , Jan 10. 92(6). pii: e02101-17. doi: 10.1128/JVI.02101-17. Print 2018 March.

3.Wang B DuanX, FuM, Liu Y, WangY, LiX, Cao H, and Zheng SJ^* The Association of Ribosomal Protein L18 (RPL18) with IBDV VP3 Enhances Viral Replication, Virus Research 2018, Feb 2;245:69-79.

4.He   Z, Chen X, Fu M, Tang J, Li X, Cao    H, Wang Y, and Zheng   SJ^*. Infectious bursal disease virus protein VP4 suppresses,   type I interferon expression via inhibiting K48-linked ubiquitylation of   glucocorticoid-induced leucine zipper (GILZ),Immunobiology 2018,   Apr – May, 223(4-5):374-382.

5.FuM, Wang B, ChenX, He Z, WangY, Li X, CaoH, and Zheng SJ^*, gga-miR-130b   suppresses infectious bursal disease virus replication via targeting the   viral genome and cellular SOCS5,J Virology 2017Dec 14;92(1). pii: e01646-17. doi:   10.1128/JVI.01646-17. Print 2018 Jan 1.

6.Qin   Y, Xu Z, Wang Y, LiX, CaoH, and Zheng   SJ^*, VP2 of Infectious Bursal Disease Virus induces apoptosis   via triggering Oral Cancer Overexpressed 1 (ORAOV1) protein degradation. Frontiers   in Microbiology2017, July,   8(1): doi:   10.3389/fmicb.2017.01351

7.Li X,   Liu Y, Wang Y, Liu J, LiXQ, Cao    H,   GaoX and Zheng SJ^*,   Negative regulation of hepatic inflammation   by the Soluble Resistance-Related Calcium Binding Protein via STAT3.Frontier in Immunology2017,   June 29, 8: 1-14 (doi: 10.3389/fimmu.2017.00709)

8.Qin   Y and Zheng SJ^* .Infectious Bursal Disease Virus-Host   Interactions: Multifunctional Viral Proteins that Perform Multiple and   Differing Jobs.International J of   Molecular Sciences2017, 18, 161;   doi:10.3390/ijms18010161

9.Xu   Z, Qin Y, Wang Y, LiX, CaoH, and Zheng   SJ^*, A   Critical role of bacterioferritin in Salmonella   pullorum-induced IFN-β expression in DF-1 cells, Frontiers in Microbiology2016,   7(1): doi: 10.3389/fmicb.2016.00020

10.Wu   H, H Z, Tang J, LiX, CaoH, Wang Y^*, and Zheng SJ^* A critical role of LAMP-1 in avian reovirus P10 degradation   associated with inhibition of apoptosis and virus release.Arch   Virol2016,161:899–911

11.Lin W, Zhang Z, Xu Z, Wang B, Wang Y, Li XQ, Cao H, and Zheng SJ^*.The Association of Receptor of Activated Protein Kinase C 1（RACK1）with Infectious Bursal   Disease Virus Protein VP5 and VDAC2 Inhibits Apoptosis and Enhances Viral   Replication. J Biol Chem. 2015, 290(13):8500-10.

12.Zhang Z,Lin W, Wu H, Wang Y, Li XQ, Cao H, and Zheng SJ^*, Critical Roles of Eukaryotic Elongation   Factor 1 alpha (eEF1A1) in Avian Reovirus Sigma   C-induced Apoptosis and Inhibition of Viral Growth. Archives of Virology2015, 160:1449–1461.

13.Zheng   W, Li X, Wang J, Li XQ, Cao H, Wang Y, Zeng Q, and Zheng SJ^*. A critical role of interferon-induced   protein IFP35 in   Foot-and-Mouth Disease Virus (FMDV)   protein 2C-induced   type I interferon response in cells.Archives of Virology2014, 159(11):2925-35.

14.Guo Z,Stephenson R,Qiu J,Zheng SJ,Luo ZQ.A Legionella effector modulates host cytoskeletal   structure by inhibiting actin polymerization, Microbes infect. 2014, 16(3):225-36.

15.Li X， Wang J，Liu J，Li Z， Wang Y， Xue Y， LI XQ，Cao H， and Zheng SJ*. Engagement of Soluble   Resistance-Related Calcium Binding Protein (sorcin) with foot-and-mouth   disease virus (FMDV) VP1 inhibits type I interferon response in cells, Vet   Microbiology 2013，166:   35–46.

16.Li   Z, Wang Y, Li X, Li XQ, Cao H, and Zheng   SJ*. Critical Roles of Glucocorticoid-Induced Leucine Zipper in   Infectious Bursal Disease Virus (IBDV)-induced Suppression of Type I   Interferon Expression and Enhancement of IBDV Growth in Host Cells via   Interaction with VP4.Journal of Virology 2013,   87(2):1221-1231.

17.Li   X, Li XQ, Cao H, Wang Y, and Zheng SJ*.   Engagement of new castle   disease virus (NDV) matrix (M) protein with charged multivesicular body   protein (CHMP) 4 facilitates viral replication. Virus Research 2013,   171: 80-88.

18.Wang   J, Wang Y, Liu J, Ding L, Zhang Q, Li X, Cao H, Tang J, and Zheng SJ*. A critical role of N-myc   and STAT interactor (Nmi) in foot-and-mouth disease virus (FMDV) 2C-induced apoptosis. Virus   Research 2012, 170 (2012) 59– 65.

19.Luo   Z, Li Z, Chen K, Liu R, Li X, Cao H, and Zheng   SJ*. Engagement of Heterogeneous Nuclear Ribonucleoprotein M with   Listeriolysin O Induces Type I Interferon Expression and Restricts Listeria   Monocytogenes Growth in Host Cells. Immunobiology 2012, 217(10):   972-981.

20.Li   Z, Wang Y, Xue Y, Li X, Cao H, and Zheng   SJ*. A critical role for voltage-dependent anion channel (VDAC) 2 in infectious bursal disease virus   (IBDV)-induced apoptosis in host cells via interacting with VP5. Journal   of Virology 2012, 86(3): 1328-1338.

21.Ruan   W, Wu Y, Zheng SJ*. Different   genetic patterns in avian Toll-like receptor (TLR)5 genes.   Mol Biol Rep. 2012，39（4）3419-26.

22.Ruan W, Wu Y, An J, Cui D, Li H, Zheng SJ*. Toll-like   receptor 2 type 1 and type 2 polymorphisms in different chicken breeds.   Poultry Science. 2012, Jan; 91(1):101-6.

23.Li L.,   Cui D., Zheng SJ., Lou HJ., Tang   J. Regulation of Actinomycin D induced upregulation of Mdm2 in H1299 cells. DNA Repair (Amst) 2012, 11(2):112-9.

24.Ruan   Q, Kameswaran V, Zhang Y, Zheng SJ, Sun J, Wang J, Devirgiliis J, Liou HC, Beg AA, Chen YH. The Th17   immune response is controlled by the Rel-ROR{gamma}-ROR{gamma}T transcriptional axis. J Exp Med. 2011 Oct   24; 208 (11):2321-33.

25.Ruan   WK, Zheng SJ*. Polymorphisms of   chicken toll-like receptor 1 type 1 and type 2 in different breeds. Poultry Science 2011,   Sep; 90(9):1941-7.

26.Li H, Li X, Lu Y, Wang X, Zheng SJ*. Staphylococcus   sciuri exfoliative toxin C is a dimer that modulates macrophage functions. Can. J.   of Microbiology 2011, 57: 722-729.

27.Li   H, Wang Y, Ding L, and Zheng SJ*   Staphylococcus sciuri exfoliative toxin C (ExhC) is   a necrosis-inducer for mammalian cells. PLoS ONE 2011, 6 (7): e23145:   1-9.

28.Li   H, He F, Zhang Z, Zheng SJ*   Critical roles of amino acids Ser231, His107 and Asp156 of Staphylococcus   sciuri exfoliative toxin C (ExhC) in the induction of skin exfoliations of   neonate. Biologia 2011: 90-11C

29.Chen   K, Luo Z, Tang J, Zheng SJ*. A   critical role of heat shock cognate protein 70 in Apoptin-induced phosphorylation of Akt.   Biochem Biophys Res Commun. 2011 Jun 3; 409(2):200-4.

30.Chen   K, Luo Z, Zheng SJ*. Gallus Heat   shock cognate protein 70, a novel binding partner of Apoptin. Virol   J. 2011 Jun 27; 8: 324-333.

31.Wang L, Zhang H, Suo X,   Zheng SJ, Feng W. Increase of CD163 but not sialoadhesin   on cultured peripheral blood monocytes is coordinated with enhanced   susceptibility to porcine reproductive and respiratory syndrome virus   infection. Veterinary Immunology and Immunopathology 2011 141: 209–220.   

32.Ruan   Q, Zheng SJ, Palmer S, Carmody RJ,   Chen YH. Roles of Bcl-3 in   the pathogenesis of murine type 1 diabetes. Diabetes 2010, Oct;   59(10):2549-57.

33.Pang   P, Chen FY, Tang J, Ma LF, Wang JC, Zheng   SJ*. Avian leukosis virus p27 inhibits tumor necrosis factor αexpression   in RAW264.7 macrophages after stimulation with lipopolysaccharide   Acta Virologica 2010, 54:119-124.

34.Wang   L, Suo X，Chen   Y and Zheng SJ* Expression of Newcastle disease virus   (NDV) M protein from a recombinant plasmid prolongs the survival of   NDV-infected chicken embryos and enhances the virus replication. Acta   Virologica 2009, 53:105-110.

35.Cheng W, An L, Wu Z, Zhu Y, Liu J, Gao H, Li, XZheng SJ, Chen D and Tian J. Effects of disulfide bond reducing   agents on sperm chromatin structural integrity and developmental competence   of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction   2009, 137: 633–643.

36.Wang Y, Lu Y, Duo Y, Wang Y,Chen F,Yang H, Zheng SJ*. Enhanced resistance of restraint stressed mice to   sepsis. Journal of Immunology 2008, 181:3441-3448.

37.Shi   K, Li H, Guo X, Ge X, Jia H, Zheng SJ, Yang H. Changes in peripheral blood leukocyte subpopulations in   piglets co-infected experimentally with porcine reproductive and respiratory   syndrome virus and porcine circovirus type 2. Veterinary Microbiology   2008, 22;129(3-4):367-77.

38.Chen   S, Wang Y, Chen F, Yang H, Menghou Gan and Zheng SJ*. A highly pathogenic strain of Staphylococcus sciuri   caused fatal exudative epidermitis in piglets. PLoS ONE 2007, 2(1)e147:   1-6.

39.Hilliard A, Hilliard B, Zheng SJ, Sun H, Takashi M, Song W and Chen YH. Translational   regulation of autoimmune inflammation and lymphoma by programmed cell death   4.   Journal of Immunology 2006,177 (11):8095-8102.

40.Zheng SJ, L-Cherradi S, Wang P, Xu LY and Chen YH. Tumor   suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 2005, 54: 1423-1428.

41.Zheng SJ, Jiang J., Shen H., and Chen YH.Reduced apoptosis and listeriosis in   TRAIL-null mice. Journal of Immunology2004,   173: 5652-5658.

42.Zheng SJ, Wang P., Tsabary G. and Chen YH. Critical role of   TRAIL in hepatic cell death and hepatic inflammation. Journal of Clinical   Investigation2004, 113(1): 58-64.

43.L-Cherridi   S^*, Zheng SJ^*(*Co-first author), Maguaschak, KA and Chen YH. Defective thymocyte   apoptosis and accelerated autoimmunune diseases in TRAIL-Null mice. Nature   Immunology2003, 4(3): 255-260. *Note: The first two authors contributed   equally to this study.

44.L-Cherradi   S, Zheng SJ and Chen YH. Critical   role of tumor necrosis factor-related apoptosis-inducing ligand in type I   diabetes. Diabetes 2003, 52: 2274-2278.

45.Zheng SJ and Chen YH. TRAIL, Bim and thymic negative   selection.Immunological Research2003, 28/3: 293-299.

46.L-Cherradi   S, Zheng SJ, Hilliard BA, Xu L, Sun   J, Alsheadat S and Chen YH. Transcriptional regulation of type I diabetes by   nuclear factor-KB. Journal of Immunology 2003,   171:4886-4892.

47.Zheng SJ, Gan MH, Yang HC and Li QH. Reproductive Failure in   sow with subclinical infection of HCV. Chinese Journal of Veterinary Medicine1997, 23 (8): 25-26.

48.Wu   JS, Zhang RJ, Zhou YP, Zheng SJ,   Yang HC and Guo YP. Optimal conditions for the chicken lymphocyte   transformation test in whole-blood assay. Chinese Journal of Animal and   Veterinary Sciences1997. 28 (3): 212-216.

49.Zheng SJ and Gan HG. 1996. Detection and Analysis of HCV   Antibody level in pigs on Intensive pig-rearing farms by ELISA method using   Monoclonal Antibody Purified HCV Antigens. Chinese Journal of Veterinary   Medicine1996, 22 (1): 17.

50.Yang   HC, YangQC, Zheng   SJ, Liu JH, Gan MH. 1996. Studies on the Detection of Antibodies against   EDS-76 Virus using Indirect Hemagglutination Assay. Chinese Journal of Veterinary   Medicine1996, 22 (2): 3-5.

51.Zhang,   Z, Yang HC and Zheng SJ.   Evaluation of the Effects of Vaccination with Bivalent IC Vaccine on Chickens   by HA Test.Chinese Journal of Veterinary Medicine1995, 21 (10): 48-50.

52.ZhaoY   and Zheng SJ. Comparable studies   on the Effect of Vertical and Horizontal Ventilation Installation system on   the Pathogenic Microorganisms in the Air of Chicken Houses. Chinese   Journal of Veterinary Medicine1994,   19 (10): 31-32.

53.Yang   HC, YangQC, Zheng   SJ Liu JH. Detection and Analysis of EDS-76 Virus Antibody Level in   Chickens by IHA Method. Proceedings of the Chinese Veterinary   Immunology1994: 66-69.

54.Yang   HC, Zhou YH, Zheng SJ and Lui JH.   Dynamics of EDS-76 Virus Multiplication in Duck Embryo. Chinese Journal of Veterinary   Medicine1994, 20 (6): 12-13.

55.Gan,MH,   Zheng SJ and Zhang Z. 1993.   Observation on the Severe reaction caused bytheInfection of Avian   Infectious Laryngotracheitis Vaccine in Flocks.Chinese Journal of Veterinary   Medicine 1993, 19 (3): 18-19.

56.Zheng SJ and Gan MH. Studies of Indirect Dot-ELISA for the   Detection of New Castle   Disease Virus. Chinese Journal of Animal and Veterinary Science1992, 23   (2): 187-191.

57.Zheng SJ and Gan MH. 1991. Studies on the Determination of   Infectious Laryngotracheitis Virus by Indirect Dot-ELISA. Chinese   Journal of Veterinary Medicine1991,   17 (3): 2-5.