动物科学技术学院

个人简介

个人简介

空格胡永飞，男，博士，教授，硕士/博士生导师。2010年7月获中国科学院微生物研究所微生物学博士学位，毕业后留所任助理研究员、副研究员。2018年6月以“杰出人才”引进中国农业大学，任动物科学技术学院教授，中国农业大学首批青年科学家创新团队负责人。

空格作为骨干和项目负责人先后承担了国家高技术研究发展计划（863）、卫生部科技重大专项、国家重点基础研究发展计划（973）、国家重点研发计划、国家自然科学基金和北京市自然科学基金等项目20余项。2010以来，在Nature Communications、The Lancet Infectious Diseases、Microbiome、Environment International、npj Biofilms and Microbiomes、The Innovation、iMeta等杂志上发表一作及通讯SCI论文53篇（IF大于10分10篇）；论文总被引5400余次，8篇论文被引超百次（单篇最高被引795次），h-index 36（Google Scholar）；发表国内核心期刊论文20余篇，授权国内发明专利8项；副主编及参编著作4部，审校译著1部。2023、2024年连续入选全球前2%顶尖科学家榜单（World’s Top 2% Scientists）。相关研究工作曾得到Nature Review Microbiology期刊两次述评；部分研究结果曾受邀入编《中国农业年鉴》。

空格目前担任中国生物工程学会微生物组学与技术专业委员会委员、噬菌体技术专业委员会委员，中国微生物学会微生物组专业委员会委员，十四五国家重点研发计划青年科学家项目咨询专家。任《微生物学报》、《生物工程学报》、《基因组学与应用生物学》编委；The Innovation杂志、iMeta杂志青年编委；Antibiotics-Basel、Front Microbiol杂志Guest Editor；Front Cell Infect Microbiol杂志Associate Editor。Nature Methods、Nature Communications、Genome Biology等杂志审稿人。曾入选中科院青年创新促进会第五批会员，并担任中科院微生物研究所青促会组长；曾获青促会“学科交叉与创新奖”、中国畜牧兽医学会青年学者讲坛优秀奖、颐和青年创新奖、中科院重点实验室年度科研成就奖（两次）、中科院微生物研究所“优秀所友”、中国农业大学优秀共产党员等奖项和荣誉。

学习与工作经历

空格2000/09-2004/07，辽宁大学生命科学院，生物科学专业，学士

空格2004/09-2007/07，辽宁大学生命科学院，微生物学专业，硕士

空格2007/09-2010/07，中国科学院微生物研究所，微生物学专业，博士

空格2010/07-2014/08，中国科学院微生物研究所，病原室，助理研究员

空格2014/09-2018/05，中国科学院微生物研究所，病原室，副研究员

空格2018/06至今，中国农业大学，动物科学技术学院，教授

研究方向

空格家禽消化道微生物组与宿主营养代谢和免疫调控；消化道微生物组与宿主发育及生产性能；基于肠道微生物的新型益生菌及酶资源挖掘与利用；细菌耐药及替抗饲料生物技术。

发表论文

1. Xu, D., Wang, X., Hou, X., Wang, X., Shi, W. *, Hu, Y*.2024 The effect of Lonicerae flos and Rhizoma curcumae longae extract on the intestinal development and function of broilers. Poult Sci, 103(11):104225. (IF₅=4.1).

2. Zhu La, A. L. T., Wen, Q., Y., Hu, D., Liu, D., Guo, Y., Hu, Y*. 2024.A New Bacillus velezensis Strain CML532 Improves Chicken Growth Performance and Reduces Intestinal Clostridium perfringens Colonization. Microorganisms, 12(4):771. (IF₅=4.8).

3. Zhu La, A. L. T., Li, D., Cheng, Z., Wen, Q., Hu, D., Jin, X., Liu, D., Feng, Y., Guo, Y., Cheng, G., & Hu, Y*. 2024. Enzymatically prepared neoagarooligosaccharides improve gut health and function through promoting the production of spermidine by Faecalibacterium in chickens. Science of The Total Environment, 912: 169057. (IF5=9.6)

4. Yang, X., Zhang, M., Liu, Y., Wei, F., Li, X., Feng, Y., Jin, X., Liu, D., Guo, Y., & Hu, Y*. 2023. Inulin-enriched Megamonas funiformis ameliorates metabolic dysfunction-associated fatty liver disease by producing propionic acid. npj Biofilms and Microbiomes, 9(1): 84. (IF5=9.4)

5. Li, D., Zhang, M., Teng Zhu La, A. L., Lyu, Z., Li, X., Feng, Y., Liu, D., Guo, Y., & Hu, Y*. 2023. Quercetin-enriched Lactobacillus aviarius alleviates hyperuricemia by hydrolase-mediated degradation of purine nucleosides. Pharmacological Research, 196: 106928. (IF5=8.8).

6. Zhang, M., Li, D., Yang, X., Wei, F., Wen, Q., Feng, Y., Jin, X., Liu, D., Guo, Y., Hu, Y*. 2023. Integrated multi-omics reveals the roles of cecal microbiota and its derived bacterial consortium in promoting chicken growth. mSystems, 8(6):e0084423. (IF5=7.3).

7. Yang, X., Li, D., Zhang, M., Feng, Y., Jin, X., Liu, D., Guo, Y., Hu, Y*. 2023. Ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota. J Anim Sci Biotechnol, 14(1):97. (IF5=7.3).

8. Z. L., A La Teng; Feng, Y., Hu, D., Feng, Y., Jin, X., Liu, D., Guo, Y., Cheng, G*., & Hu, Y*. 2023. Enzymatically prepared alginate oligosaccharides improve broiler chicken growth performance by modulating the gut microbiota and growth hormone signals. J Anim Sci Biotechnol, 14(1):96. (IF5=7.3, Featured Article).

9. Feng, Y., Zhang, M., Liu, Y., Yang, X., Wei, F., Jin, X., Liu, D., Guo, Y*., & Hu, Y*. 2023. Quantitative microbiome profiling reveals the developmental trajectory of the chicken gut microbiota and its connection to host metabolism.iMeta, e105. (IF=23.7).

10. Zhang, J., Feng, Y*., & Hu, Y*. 2023. Integration of SNP genotyping and 16S rRNA amplicon sequencing to identify heritable gut microbes in chickens. STAR Protocols, 4(1): 102071.(Featured Article).

11. Hu, Y*., Liu, D., Jin, X., Feng, Y., & Guo, Y*. 2023. Synthetic microbiome for a sustainable poultry industry. The Innovation, 4(1): 100357. (IF=32.1).

12. Sun, D.*, Sun, X.*, Hu, Y.*, Yamaichi, Y*. 2023. Editorial: Horizontal gene transfer mediated bacterial antibiotic resistance, volume II. Front Microbiol, 14:1221606.

13. Dong, Y., Feng, Y., Ou, X., Liu, C., Fan, W., Zhao, Y., Hu, Y*., & Zhou, X*. 2022. Genomic analysis of diversity, biogeography, and drug resistance in Mycobacterium bovis. Transbound Emerg Dis, 1-10. (IF5=4.529).

14. Feng, Y., Liu, D., Liu, Y., Yang, X., Zhang, M., Wei, F., Li, D., Hu, Y*., & Guo, Y*. 2022. Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickens. iScience, 25(6): 104469. (IF5=6.233).

15. Wu, N., Feng, Y., Lyu, N., Wang, D., Yu, W., & Hu, Y*. 2022. Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model. World J Gastroenterol, 28(18): 1981-1995. (IF5=5.715).

16. Xu, C., Wei, F., Yang, X., Feng, Y., Liu, D., & Hu, Y*. 2022. Lactobacillus salivarius CML352 Isolated from Chinese Local Breed Chicken Modulates the Gut Microbiota and Improves Intestinal Health and Egg Quality in Late-Phase Laying Hens. Microorganisms, 10: 726. (IF5=5.143).

17. Feng, Y., Wang, Y., Zhu, B., Gao, G. F., Guo, Y., & Hu, Y*. 2021. Metagenome-assembled genomes and gene catalog from the chicken gut microbiome aid in deciphering antibiotic resistomes. Commun Biol, 4: 1305. IF5=6.816).

18. Lyu, N., Feng, Y., Pan, Y., Huang, H., Liu, Y., Xue, C., Zhu, B., & Hu, Y.*2021. Genomic Characterization of Salmonella enterica Isolates From Retail Meat in Beijing, China. Front Microbiol, 12:636332. (IF5=6.843).

19. Pan, Y., Fang, Y., Feng, Y., Lyu, N., Chen, L., Li, J., Xu, X., Zhu, B., & Hu, Y*. 2021. Discovery of mcr-3.1 gene carried by a prophage located in a conjugative IncA/C2 plasmid from a Salmonella Choleraesuis clinical isolate. J Infect,82(3):414-451. (IF5=19.923).

20. Pan, Y., Fang, Y., Song, X., Lyu, N., Chen, L., Feng, Y., Xu, X., Zhu, B., & Hu, Y*.2021. Co-occurrence of mcr-9, extended spectrum beta-lactamase (ESBL) and AmpC genes ina conjugative IncHI2A plasmid from a multidrug-resistant clinical isolate of Salmonella diarizonae. J Infect, 82(4):84-123. (IF5=19.923).

21. Wang, Y., Lyu, N., Liu, F., Liu, W. J., Bi, Y., Zhang, Z., Ma, S., Cao, J., Song, X., Wang, A., Zhang, G., Hu, Y.*, Zhu, B.*, & Gao, G. F.* 2021. More diversified antibiotic resistance genes in chickens and workers of the live poultry markets. Environ Int, 153: 106534. (IF5=13.238).

22. Cao, J.^#, Hu, Y.^#, Liu, F.^#, Wang, Y., Bi, Y., Lv, N., Li, J., Zhu, B., & Gao, G. F. 2020. Metagenomic analysis reveals the microbiome and resistome in migratory birds. Microbiome, 8(1): 26. (IF5=19.813).

23. Cao, L., Chen, H., Wang, Q., Li, B., Hu, Y., Zhao, C., Hu, Y.*, & Yin, Y*. 2020. Literature-Based Phenotype Survey and In Silico Genotype Investigation of Antibiotic Resistance in the Genus Bifidobacterium. Curr Microbiol, 77: 4104–4113. (IF5=2.408).

24. Feng, Y., Fan, X., Zhu, L., Yang, X., Liu, Y., Gao, S., Jin, X., Liu, D., Ding, J., Guo, Y., & Hu, Y.* 2020. Phylogenetic and genomic analysis reveals high genomic openness and genetic diversity of Clostridium perfringens. Microb Genom, 6(10): mgen000441. (IF5=7.142).

25. Wang, Y.^#, Hu, Y.^#, Liu, F., Cao, J., Lv, N., Zhu, B., Zhang, G., & Gao, G. F. 2020. Integrated metagenomic and metatranscriptomic profiling reveals differentially expressed resistomes in human, chicken, and pig gut microbiomes. Environ Int, 138: 105649. (IF5=13.238).

26. Wang, Y.^#, Hu, Y.^#, Cao, J., Bi, Y., Lv, N., Liu, F., Liang, S., Shi, Y., Jiao, X., Gao, G. F., & Zhu, B. 2019. Antibiotic resistance gene reservoir in live poultry markets. J Infect, 78(6):445-453.(IF5=19.923).

27. Hu, Y., Feng, Y., Wu, J., Liu, F., Zhang, Z., Hao, Y., Liang, S., Li, B., Li, J., Lv, N., Xu, Y.*, Zhu, B.*, & Sun, Z*. 2019. The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients. Front Cell Infect Microbiol, 9:90. (IF5=6.340).

28. Song, X., Zhong, L., Lyu, N., Liu, F., Li, B., Hao, Y., Xue, Y., Li, J., Feng, Y., Ma, Y., Hu, Y.*, & Zhu, B.* 2019. Inulin Can Alleviate Metabolism Disorders in ob/ob Mice by Partially Restoring Leptin-related Pathways Mediated by Gut Microbiota. Genomics Proteomics Bioinformatics, 17(1):64-75. (IF5=10.196).

29. Liu, W. J.#, Zou, R.#, Hu, Y.#, Zhao, M., Quan, C., Tan, S., Luo, K., Yuan, J., Zheng, H., Liu, J., Liu, M., Bi, Y., Yan, J., Zhu, B., Wang, D., Wu, G., Liu, L., Yuen, K. Y., Gao, G. F., & Liu, Y. 2018. Clinical, immunological and bacteriological characteristics of H7N9 patients nosocomially co-infected by Acinetobacter Baumannii: a case control study. BMC Infect Dis, 18(1): 664.

30. Alkasir, R., Ma, Y., Liu, F., Li, J., Lv, N., Xue, Y., Hu, Y.*, & Zhu, B*. 2018. Characterization and Transcriptome Analysis of Acinetobacter baumannii Persister Cells. Microb Drug Resist, 24(10): 1466-1474.

31. Lu, X.^#, Hu, Y.^#, Luo, M., Zhou, H., Wang, X., Du, Y., Li, Z., Xu, J., Zhu, B., Xu, X., & Kan, B. 2017. MCR-1.6, a New MCR Variant Carried by an IncP Plasmid in a Colistin-Resistant Salmonella enterica Serovar Typhimurium Isolate from a Healthy Individual. Antimicrob Agents Chemother, 61(5): e02632-16.

32. Hu, Y.*, Gao, G. F., & Zhu, B*. 2017. The antibiotic resistome: gene flow in environments, animals and human beings. Front Med, 11(2): 161-168.

33. Hu, Y., & Zhu, B. 2016. The Human Gut Antibiotic Resistome in the Metagenomic Era: Progress and Perspectives. Infect Dis Transl Med, 2(1): 41-47.

34. Hu, Y., Yang, X., Li, J., Lv, N., Liu, F., Wu, J., Lin, I. Y., Wu, N., Weimer, B. C., Gao, G. F., Liu, Y., & Zhu, B. 2016. The Bacterial Mobile Resistome Transfer Network Connecting the Animal and Human Microbiomes. Appl Environ Microbiol, 82(22): 6672-6681.

35. Hu, Y., Liu, F., Lin, I. Y., Gao, G. F., & Zhu, B. 2016. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis, 16(2): 146-147.

36. Gao, R.^#, Hu, Y.^#, Li, Z.^#, Sun, J.^#, Wang, Q., Lin, J., Ye, H., Liu, F., Srinivas, S., Li, D., Zhu, B., Liu, Y. H., Tian, G. B., & Feng, Y. 2016. Dissemination and Mechanism for the MCR-1 Colistin Resistance. PLoS Pathog, 12(11): e1005957.

37. Liu, F., Yang, X., Wang, Z., Nicklasson, M., Qadri, F., Yi, Y., Zhu, Y., Lv, N., Li, J., Zhang, R., Guo, H., Zhu, B., Sjoling, A.*, & Hu, Y*. 2015. Draft genomes of four enterotoxigenic Escherichia coli (ETEC) clinical isolates from China and Bangladesh. Gut Pathog, 7: 10.

38. Li, H., Liu, F., Zhang, Y., Wang, X., Zhao, C., Chen, H., Zhang, F., Zhu, B., Hu, Y.*, & Wang, H.* 2015. Evolution of carbapenem-resistant Acinetobacter baumannii revealed through whole-genome sequencing and comparative genomic analysis. Antimicrob Agents Chemother, 59(2): 1168-1176.

39. Hu, Y., Zhu, Y., Ma, Y., Liu, F., Lu, N., Yang, X., Luan, C., Yi, Y., & Zhu, B. 2015. Genomic insights into intrinsic and acquired drug resistance mechanisms in Achromobacter xylosoxidans. Antimicrob Agents Chemother, 59(2): 1152-1161.

40. Hu, Y.^#, Liu, Y^#., Li, J., Feng, Y., Lu, N., Zhu, B., & Xue, S. 2015. Structural and functional analysis of a low-temperature-active alkaline esterase from South China Sea marine sediment microbial metagenomic library. J Ind Microbiol Biotechnol, 42(11): 1449-1461.

41. Zhu, Y., Yi, Y., Liu, F., Lv, N., Yang, X., Li, J., Hu, Y.*, & Zhu, B*. 2014. Distribution and molecular profiling of class 1 integrons in MDR Acinetobacter baumannii isolates and whole genome-based analysis of antibiotic resistance mechanisms in a representative strain. Microbiol Res, 169(11): 811-816.

42. Yi, Y., Lu, N., Liu, F., Li, J., Zhang, R., Jia, L., Jing, H., Xia, H., Yang, Y., Zhu, B., Hu, Y.*, & Cui, Y*. 2014. Genome sequence and comparative analysis of a Vibrio cholerae O139 strain E306 isolated from a cholera case in China. Gut Pathog, 6(1): 3.

43. Lu, N.^#, Hu, Y.^#, Zhu, L.^#, Yang, X., Yin, Y., Lei, F., Zhu, Y., Du, Q., Wang, X., Meng, Z., & Zhu, B. 2014. DNA microarray analysis reveals that antibiotic resistance-gene diversity in human gut microbiota is age related. Sci Rep, 4: 4302.

44. Liu, F., Zhu, Y., Yi, Y., Lu, N., Zhu, B.*, & Hu, Y*. 2014. Comparative genomic analysis of Acinetobacter baumannii clinical isolates reveals extensive genomic variation and diverse antibiotic resistance determinants. BMC Genomics, 15: 1163.

45. Liu, F.^#, Hu, Y.^#, Wang, Q., Li, H. M., Gao, G. F., Liu, C. H., & Zhu, B. 2014. Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates. BMC Genomics, 15: 469.

46. Hu, Y., Yang, X., Lu, N., & Zhu, B. 2014. The abundance of antibiotic resistance genes in human guts has correlation to the consumption of antibiotics in animal. Gut Microbes, 5(2): 245-249.

47. Li, B.^#, Hu, Y.^#, Wang, Q.^#, Yi, Y., Woo, P. C., Jing, H., Zhu, B., & Liu, C. H. 2013. Structural diversity of class 1 integrons and their associated gene cassettes in Klebsiella pneumoniae isolates from a hospital in China. PLoS One, 8(9): e75805.

48. Hu, Y.^#, Yang, X.^#, Qin, J., Lu, N., Cheng, G., Wu, N., Pan, Y., Li, J., Zhu, L., Wang, X., Meng, Z., Zhao, F., Liu, D., Ma, J., Qin, N., Xiang, C., Xiao, Y., Li, L., Yang, H., Wang, J., Yang, R., Gao, G. F., Wang, J., & Zhu, B. 2013. Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota. Nat Commun, 4: 2151.

49. Hu, H.^#, Hu, Y.^#, Pan, Y., Liang, H., Wang, H., Wang, X., Hao, Q., Yang, X., Yang, X., Xiao, X., Luan, C., Yang, Y., Cui, Y., Yang, R., Gao, G. F., Song, Y., & Zhu, B. 2012. Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii. Antimicrob Agents Chemother, 56(4): 1698-1702.

50. Hu, Y.^#, Zhang, W.^#, Liang, H., Liu, L., Peng, G., Pan, Y., Yang, X., Zheng, B., Gao, G. F., Zhu, B., & Hu, H. 2011. Whole-genome sequence of a multidrug-resistant clinical isolate of Acinetobacter lwoffii. J Bacteriol, 193(19): 5549-5550.

51. Fu, C.^#, Hu, Y.^#, Xie, F., Guo, H., Ashforth, E. J., Polyak, S. W., Zhu, B., & Zhang, L. 2011. Molecular cloning and characterization of a new cold-active esterase from a deep-sea metagenomic library. Appl Microbiol Biotechnol, 90(3): 961-970.

52. Hu, Y., Fu, C., Yin, Y., Cheng, G., Lei, F., Yang, X., Li, J., Ashforth, E. J., Zhang, L., & Zhu, B. 2010. Construction and preliminary analysis of a deep-sea sediment metagenomic fosmid library from Qiongdongnan Basin, South China Sea. Mar Biotechnol (NY), 12(6): 719-727.

53. Hu, Y., Fu, C., Huang, Y., Yin, Y., Cheng, G., Lei, F., Lu, N., Li, J., Ashforth, E. J., Zhang, L., & Zhu, B. 2010. Novel lipolytic genes from the microbial metagenomic library of the South China Sea marine sediment. FEMS Microbiol Ecol, 72(2): 228-237.

54. 胡蝶，阿拉腾珠拉，程志钱，张美红，肖瑀轩，程功，胡永飞*。褐藻寡糖对肉鸡生长性能、免疫器官指数、血清抗氧化指标和肠道健康的影响。动物营养学报，2024, 36(4): 2331-2343。

55. 阿拉腾珠拉，胡永飞*。组学视角下养殖动物消化道微生物组结构与功能研究进展。微生物学报，2023, 63(5): 1850-1862。

56. 肖瑀轩，赵舒然，文秋，徐畅，封雨晴，胡永飞*。鸡源暹罗芽孢杆菌CML548的益生特性及全基因组分析。微生物学通报，2023, 50(02): 584-599。

57. 胡永飞，呙于明。家禽肠道微生物组研究进展。中国家禽，2022, 44(11): 1-9。

58. 阿拉腾珠拉，胡永飞*。褐藻寡糖的制备方法及生物活性研究进展。生物工程学报，2022, 38(4): 1-14。

59. 胡永飞。微生物组学研究的“淘金时代”。微生物学报，2019, 9: 1631-1635。

60. 胡永飞，朱宝利。细菌耐药专刊序言。生物工程学报，2018, 8: 1201-1204。

61. 王亚楠，胡永飞*，朱宝利，焦新安，高福。养殖动物及其相关环境耐药组的研究进展。生物工程学报，2018，34(8): 1226-1233。

62. 马亚男，朱玉莹，李维城，刘飞，律娜，李晶，朱宝利^*，胡永飞^*。鲍曼不动杆菌耐药持留菌的特征及Ⅱ型毒素-抗毒素系统的多样性。微生物学报，2015, 55(7): 949-958.

63. 朱玉莹，易勇，杨犀，律娜，李晶，朱宝利^*，胡永飞^*。多重耐药铜绿假单胞菌中Ⅰ型整合子新结构的发现及其与耐药的相关性。微生物学报，2013, 53(9): 927-932.

64. 胡永飞，李铁民，张博，杨志勇，李玉。抗噬菌体重组钝齿棒杆菌的生理稳定性。2010, 30(6): 51-54。

65. 胡永飞，李铁民，杨智勇等。限制修饰系统cglI 赋予钝齿棒杆菌抗噬菌体功能活性。生物工程学报，2008, 24(5): 760-765。

66. 胡永飞，李铁民。基因工程技术在建立噬菌体抗性机制研究中的应用。微生物学杂志，2006, 26(6): 89-91。

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