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个人简介俞英,博士,中国农业大学动物科学技术学院教授,博士生导师,小精尖领域奶牛抗病育种首席专家,国家级一流本科课程《动物育种学》负责人,“大北农”教学名师,中国奶业杰出科技人才。国际家养动物FarmGTEx联合组织成员、第三次全国牛遗传资源普查国家级专家组成员,兼任中国畜牧兽医学会动物遗传育种学分会理事、养牛学分会理事、畜禽遗传标记学分会理事,中国奶业协会育种专业委员会委员。主要研究方向包括动物疾病抗性的遗传基础及表观遗传调控、奶牛乳房炎风险评估及应用、畜禽表观遗传修饰的代间传递规律及在抗病遗传育种中的应用。曾担任2020动物&人类健康与表观遗传调控在线研讨会执行主席,2018国际动物健康及抗病遗传育种研讨会大会秘书长。以第一或通讯(含并列)作者在Nature Genetics、Molecular Biology and Evolution、Advanced Science、BMC Biology、JASB、FASEB J、JDS、畜牧兽医学报、中国科学等高水平国际国内期刊发表论文170余篇。担任Small Ruminant Research、Journal of Integrative Agriculture、Frontiers in Genetics等期刊编辑(含专刊编辑)。副主编国家级规划教材《动物育种学实验教程》,参编《动物重要经济性状基因的分离与应用》、《Livestock Epigenetics》、《10000个科学难题》等专著。获省部级科研奖励8项、国家级及省部级教学奖励8项,授权国家发明专利10项。 教学科研概况社会职务1. 动物&人类健康与表观遗传调控国际在线研讨会,执行主席 2. 国际动物健康及抗病遗传育种研讨会,大会秘书长 3. 中国畜牧兽医学会动物遗传育种学分会,理事 4. 中国畜牧兽医学会养牛学分会,理事 5. 中国畜牧兽医学会畜禽遗传标记学分会,理事 6. 中国奶业协会育种专业委员会,委员 7. 中国农业大学动物科学技术学院小精尖领域 奶牛抗病育种,首席专家 8. 中国农业大学动科院“牛百科”本科生育人平台,主创人之一 9. 担任NSFC面上项目、青年项目、联合基金等项目,评审专家 10. 担任《Molecular Biology and Evolution》《Frontiers in Immunology》、《Journal of Animal Science and Biotechnology》、《Journal of Dairy Science》、《FEBS J》、《Genomics》、《Animal Frontiers》、《BMC Genomics》、《BMC Genetics》、《Animal Genetics》、《Animal》、《Gene》、《Journal of Animal Science》、《畜牧兽医学报》、《中国畜牧杂志》、《中国农业科学》、《遗传》等SCI期刊及中文核心期刊审稿专家 活动动态研究领域1. 奶牛抗病育种 2. 动物健康的遗传及表观遗传调控机制及应用 3. 畜禽表观遗传修饰的代间传递规律及在抗病遗传育种中的应用 开授课程
本科生课程:近十年课程数据
科研项目
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论文
论文主要发表文章(* 通讯作者,#同等贡献作者): https://doi.org/10.1038/s42003-026-09605-y https://doi.org/10.1186/s12864-025-11430-2 4. , Siyuan Mi, , Siqian Chen, , David E MacHugh, Functional validation to explore the protective role of miR-223 in Staphylococcus aureus-induced bovine mastitis. Journal of Animal Science and Biotechnology, 2025, 16(1):34. 5. Qingyao Zhao, Jiahao Wang, Fuping Ma, Quanzhen Chen, Huatao Liu, Jinyan Yang, Siqian Chen, Yongjie Tang, Siyuan Mi, , Xini Wang, Guohong Liu, Kai Xing, Ying Yu, Chuduan WangThe comprehensive transcriptomic atlas of porcine immune tissues and the peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genes, Journal of Animal Science and Biotechnology, 2025, 16(1):69. 6. Songyan An, Songyan An, Siyuan Mi, Siqian Chen, Yongjie Tang, Yue Xing, Yi Jing, Ying Yu. Unraveling key transposable elements in pathogen-induced bovine mastitis through comparative in vivo and in vitro transcriptomic analysis, BMC Genomics, 2025, 26(1):611. DOI: 10.1186/s12864-025-11740-5 7. Yue Xing, Siyuan Mi, Siqian Chen, Xinyue Tao, , Yuanjun Shi, , YTHDF2-mediated m6A modification regulates mRNA stability of Immediate early response gene 3 to modulate cell death in Staphylococcus aureus-induced bovine mastitis, Frontiers in Cellular and Infection Microbiology, 2025, 15:1542647. doi: 10.3389/fcimb.2025.1542647. 8. Yue Xing, Siyuan Mi, Gerile Dari, Zihan Zhang, Siqian Chen, Ying Yu. Ferroptosis-Related Genes as Molecular Markers in Bovine Mammary Epithelial Cells Challenged with Staphylococcus aureus, International Journal of Molecular Sciences, 2025, 26(6):2506. doi: 10.3390/ijms26062506. 9. Jiahao Wang#, Menghua Zhang #, Qingyao Zhao, Siqian Chen, Yongjie Tang, Quanzhen Chen, Lei Xu, Dan Wang, Xiaoping Guo, Kai Xing, Yachun Wang, ChuduanWang, Xixia Huang*, Ying Yu*. Characterizing age-related features for assessing biological age and characteristics in Xinjiang Brown cattle, BMC Genomics, 2025, 26(1):542. doi: 10.1186/s12864-025-11430-2. 10. YN Wang, S Q Chen, Y J Tang, Q Z Chen, J H Wang, Y F Bai, Y L Zhou, H H Xu, W L Li, J Chen, J H Cui, Y C Wang, Y L Zhang, Y Yu*. Identification of the key genes in Sanhe cattle for health and milk composition traits based on the weighted gene co-expression network analysis, Journal of Dairy Science, 2025, 108(7):7741-7757. doi: 10.3168/jds.2024-25842. 11. Quanzhen Chen, Siqian Chen, Yongjie Tang, Qingyao Zhao, Xilai Zhu, Li Zhi, Xiao Feng, Huaming Mao, Kaixing Qu*, Ying Yu*. Integration of genome and transcriptome reveals core genes and allele-specific expression genetic variants associated with immune differentiation of taurine ancestry dairy cattle from indicine ancestry cattle, BMC Genomics, 2025, 26(1):778. doi: 10.1186/s12864-025-11936-9. 12. Siqian Chen‡, Shuli Liu‡, Shaolei Shi‡, Hongwei Yin, Yongjie Tang, Jinning Zhang, Wenlong Li, Gang Liu, Kaixing Qu, Xiangdong Ding, Yachun Wang, Jianfeng Liu, Shengli Zhang, Lingzhao Fang,* and Ying Yu*. Cross-Species Comparative DNA Methylation Reveals Novel Insights into Complex Trait Genetics among Cattle, Sheep, and Goats. Mol. Biol. Evol. 2024,41(2): msae003 https://doi.org/10.1093/molbev/msae003 13. Yongjie Tang, Jinning Zhang, Wenlong Li, Xueqin Liu, Siqian Chen, Siyuan Mi, Jinyan Yang, Jinyan Teng, Lingzhao Fang* and Ying Yu* Identification and characterization of whole blood gene expression and splicing quantitative trait loci during early to mid- lactation of dairy cattle, BMC Genomics. 2024, 25:445. https://doi.org/10.1186/s12864-024-10346-7 14. Yue Xing1, Yongjie Tang1, Quanzhen Chen1, Siqian Chen1, Wenlong Li1, Siyuan Mi1,*,and Ying Yu1,* The role of RNA epigenetic modification-related genes in the immune response of cattle to mastitis induced by Staphylococcus aureus. Anim Biosci 37(7):1141-1155. July 2024 https://doi.org/10.5713/ab.23.0323 15. Xiao Wang#, Wenlong Li#, Xia Feng, Jianbin Li, George E. Liu, Lingzhao Fang* and Ying Yu*. Harnessing male germline epigenomics for the genetic improvement in cattle. Journal of Animal Science and Biotechnology, 2023, 14:76. 16. Wenlong Li, Siyuan Mi, Jinning Zhang, Xueqin Liu, Siqian Chen, Shuli Liu, Xia Feng, Yongjie Tang, Yanhua Li, Lin Liu, Lingzhao Fang, Shengli Zhang, and Ying Yu*. Integrating sperm cell transcriptome and seminal plasma metabolome to analyze the molecular regulatory mechanism of sperm motility in Holstein stud bulls. 2023, Journal of Animal Science, 2023, 101, 1–15. 17. Xueqin Liu, Siyuan Mi, Wenlong Li, Jinning Zhang, Serafino M. A. Augustino, Zhichao Zhang, Ruiqiang Zhang, Wei Xiao and Ying Yu*. Molecular regulatory mechanism of key LncRNAs in subclinical mastitic cows with folic acid supplementation. BMC Genomics, 2023, 24:464. 19. Zhang, Hailiang#; Mi#, Siyuan; Hu, Lirong; Wang, Lei; Ma, Longgang; Yu, Ying*; Wang, Yachu*. Genomic and transcriptomic analyses enable the identification of important genes associated with subcutaneous fat deposition in Holstein cows. JGG, 2023, https://doi.org/10.1016/j.jgg.2023.01.011 21. Chen S, Liu S, Shi S, Jiang Y, Cao M, Tang Y, Liu J, Fang L*, Yu Y* and Zhang S. Comparative epigenomics reveals the impact of ruminant-specific regulatory elements on complex traits[J]. BMC Biology 20, 273 (2022). doi:10.1186/s12915-022-01459-0. 22. Q. Z. Chen#, M. Y. Yang#, X. Q. Liu, J. N. Zhang, S. Y. Mi, Y. J. Wang, W. Xiao, and Y. Yu* Blood transcriptome analysis and identification of genes associated with supernumerary teats in Chinese Holstein cows. Journal of Dairy Science. 2022. S0022-0302(22)00591-4. https://doi.org/10.3168/jds.2022-22346 23. Jinning Zhang, Xueqin Liu, Tahir Usman, Yongjie Tang, Siyuan Mi, Wenlong Li, Mengyou Yang, and Ying Yu,* Integrated analysis of transcriptome and milk metagenome in subclinical mastitic and healthy cows. Animal Bioscience. 2023. https://doi.org/10.5713/ab.21.0495 online published 24. Muhammad Zahoor Khan#, Gerile Dari#, Adnan Khan , Ying Yu*. Genetic polymorphisms of TRAPPC9 and CD4 genes and their association with milk production and mastitis resistance phenotypic traits in Chinese Holstein. Frontiers in Veterinary Science. 2022, 9:1008497. https://doi.org/10.3389/fvets.2022.1008497. (Sep.23) 25. Jinyan Yang, Yongjie Tang, Xueqin Liu, Jinning Zhang, Muhammad Zahoor Khan, Siyuan Mi, Chuduan Wang, Ying Yu*. Characterization of Peripheral White Blood Cells Transcriptome Profiles to Unravel the Regulatory Signatures of Bovine Subclinical Mastitis Resistance. Frontiers in Genetics. 2022. 13:949850. doi: 10.3389/fgene.2022.949850. (Sep.20) 26. Siyuan Mi#, Yuanjun Shi#, Gerile Dari, and Ying Yu*. Function of m6A and its regulation of domesticated animals’ complex traits. Journal of Animal Science, 2022, 11(6): 1-14. https://doi.org/10.1093/jas/skac034 27. Mi SY#, Tang YJ#, Shi LY, Liu XQ, Si JF, Yao YL, Augustino SMA, Fang LZ, Yu Y*. Protective roles of folic acid in the responses of bovine mammary epithelial cells to different virulent Staphylococcus aureus strains. Biology, 2021, 10, 1164. https://doi.org/10.3390/biology10111164 28. Mi SY#, Chen SQ#, Li WL, Fang LZ, Yu Y*. Effects of sperm DNA methylation on domesticated animal performance and perspectives on cross-species epigenetics in animal breeding, Animal Frontiers, 2021, 11(6): 39-47. doi: 10.1093/af/vfab053. 29. Siyuan Mi, Yongjie Tang, Darigerile, Yuanjun Shi, Jinning Zhang, Hailiang Zhang, Xueqin Liu, Yibing Liu, Usman Tahir, Ying Yu*. Transcriptome sequencing analysis for the identification of stable lncRNAs associated with bovine Staphylococcus aureus mastitis, Journal of Animal Science and Biotechnology. 2021, 12(1):120.doi.org/10.1186/s40104-021-00639-2 30.Ying Yu, Siqian Chen, Shuli Liu, Lingzhao Fang, Shengli Zhang. Studies of sperm DNA methylation variations and their potential regulations on production and reproduction traits in cattle and pigs. Journal of Animal Science, 2021. 99(S3): 88. 31.Serafino M. A. Augustino, Qinglei Xu, Xueqin Liu, Siyuan Mi, Liangyu Shi, Yibing Liu, Hui Wen, Di Wang, Lei Liu, Qin Zhang and Ying Yu*. Integrated analysis of lncRNAs and mRNAs reveals key trans-target genes associated with ETEC-F4ac adhesion phenotype in porcine small intestine epithelial cells, BMC Genomics, 2020, 21:780. https://doi.org/10.1186/s12864-020-07192-8. 34. Serafino M. A. Augustino, Qinglei Xu, Xueqin Liu, Lei Liu, Qin Zhang, Ying Yu*. Transcriptomic Study of Porcine Small Intestine Epithelial Cells Reveals Important Genes and Pathways Associated with Susceptibility to Escherichia coli F4ac Diarrhea. Frontiers in Genetics, 2020, 2: 68. doi: 10.3389/fgene.2020.00068. 35. Muhammad Zahoor Khan, Lei Liu, Zhichao Zhang, Adnan Khan, Di Wang, Siyuan Mi, Tahir Usman, Gang Liu, Gang Guo, Xizhi Li, Yachun Wang, Ying Yu*. Folic acid supplementation regulates milk production variables, metabolic associated genes and pathways in perinatal Holsteins, J Anim Physiol Anim Nutr (Berl), 2020, 104(2): 483-492. 36. Khan MZ, Zhang Z, Liu L, Wang D, Mi S, Liu X, Liu G, Guo G, Li X, Wang Y, Yu Y*. Folic acid supplementation regulates key immunity-associated genes and pathways during the periparturient period in dairy cows. Asian-Australasian Journal of Animal Sciences (AJAS), 2020, 00:1-13 doi:10.5713/ajas.18.0852. 37. Di Wang, Yiyuan Wei, Liangyu Shi, Muhammad Zahoor Khan, Lijun Fan, Yachun Wang, and Ying Yu*. Genome-wide DNA methylation pattern in a mouse model reveals two novel genes associated with Staphylococcus aureus mastitis. Asian-Australasian Journal of Animal Sciences (AJAS), 2020, 33(2):203-211. doi: 10.5713/ajas.18.0858 38. Lei Liu, Di Wang, Siyuan Mi, Zhongyi Duan, Shuang Yang, Jiuzhou Song, Guiyun Xu, Ning Yang, and Ying Yu*. The different effects of viral and bacterial mimics maternal stimuli on ethology of hens and reproduction of their offspring. Poultry Science, 2019, 98(9):4153-4160. doi: 10.3382/ps/pez189. 39. Khan MZ, Wang D, Liu L, Usman T, Wen H, Ruiqiang Z, Liu SL, Shi LY, Mi SY, Xiao W, Yu Y*. Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins, Journal of Dairy Research, 2019. 86(4):388-393. doi.org/10.1017/S0022029919000682 40. Liu L, Yang N, Xu GY, Liu SL, Wang D, Song JZ, Duan ZY, Yang S, Yu Y*.Transgenerational transmission of maternal stimulatory experience in domesticated birds. The FASEB Journal, 2018.12:7002-7017. doi: 10.1096/fj.201800762RR 41. Tahir Usman#, Yachun Wang#, Chao Liu#, Yanghua He, Xiao Wang, Yichun Dong, Hongjun Wu, Airong Liu, Ying Yu*. Novel SNPs in IL-17F and IL-17A genes associated with somatic cell count in Chinese Holstein and Inner-Mongolia Sanhe cattle, Journal of Animal Science and Biotechnology. 2017, 8:5. doi: 10.1186/s40104-016-0137-1. 42. Song M, He Y, Zhou H, Zhang Y, Li X, Yu Y*. Combined analysis of DNA methylome and transcriptome reveal novel candidate genes with susceptibility to bovine Staphylococcus aureus subclinical mastitis. Sci. Rep. 2016,6:29390. doi: 10.1038/srep29390. 43. He Y, Song M, Zhang Y, Li X, Song J, Zhang Y, Yu Y*. Whole-genome regulation analysis of histone H3 lysin 27 trimethylation in subclinical mastitis cows infected by Staphylococcus aureus. BMC Genomics. 2016, 17:565. doi: 10.1186/s12864-016-2947-0. 44. Lingzhao Fang, Yali Hou, Jing An, Bingjie Li, Minyan Song, Xiao Wang, Peter Sørensen, Yichun Dong, Chao Liu, Yachun Wang, Huabin Zhu, Shengli Zhang and Ying Yu*. Genome-wide Transcriptional and Post-transcriptional Regulation of Innate Immune and Defense Responses of Bovine Mammary Gland to Staphylococcus aureus. Front. Cell. Infect. Microbiol. 2016, doi: 10.3389/fcimb.2016.00193. 45. Shen JY, Zhou CL, Zhu SE, Shi WQ, Hu MS, Fu XW, Wang CD, Wang YC, Zhang Q, Ying Yu* Comparative transcriptome analysis reveals early pregnancy-specific genes expressed in peripheral blood of pregnant sows PLoS ONE, 2014 Dec 5;9(12):e114036. 46. Usman T, Wang Y, Liu C, Wang X, Zhang Y. and Yu Y.*Association study of single nucleotide polymorphisms in JAK2 and STAT5B genes and their differential mRNA expression with mastitis susceptibility in Chinese Holstein cattle. Animal Genetics. 2015, 46(4):371-380. 47. Wang X, Ma PP, Liu JF, Zhang Q, Zhang Y, Ding XD, Jiang L, Wang YC, Zhang Y, Sun DX, Zhang SL, Su GS and Yu Y*. Genome-wide association study in Chinese Holstein cows reveal two candidate genes for somatic cell score as an indicator for mastitis susceptibility. BMC Genetics. 2015, 16:111. 48. Wang X, Wang X, Wang Y, Guo G, Usman T, Hao D, Tang X, Zhang Y, Yu Y*. Antimicrobial Resistance and Toxin Genes Profiles of Staphylococcus aureus Strains from Holstein Milk. Letters in Applied Microbiology. 2014, 58(6):527-34(Jan 25, 4DOI: 10.1111/lam.12221.) 49. Liu X , Usman T, Wang YC, Zezhao Wang, Xianzhou Xu, Meng Wu, Yi Zhang, Xu Zhang, Qiang Li, Lin Liu,Wanhai Shi, Chunhua Qin, Fanjun Geng, Congyong Wang, Rui Tan, Xixia Huang, Airong Liu, Hongjun Wu, Shixin Tan, Yu Y*. Polymorphisms in Epigenetic and Meat Quality Related Genes in Fourteen Cattle Breeds and Association with Beef Quality and Carcass Traits. Asian-Australasian Journal of Animal Sciences (AJAS) 2015; 28(4): 467-475. 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Jinning Zhang , Wenlong Li, Yongjie Tang, Xueqin Liu, Hailiang Zhang, Yueling Zhou, Yachun Wang , Wei Xiao*, and Ying Yu ,* Testing two somatic cell count cutoff values for bovine subclinical mastitis Detection Based on Milk Microbiota and Peripheral Blood Leukocyte Transcriptome Profile. Animals. 2022, 12: 1694. https://doi.org/10.3390/ani12131694 54. Tahir Usman*, Nawab Ali, Yachun Wang and Ying Yu* Association of Aberrant DNA Methylation Level in the CD4 and JAK-STAT-Pathway-Related Genes with Mastitis Indicator Traits in Chinese Holstein Dairy Cattle, Animals.2021. 12(1):65. doi: 10.3390/ani12010065. (2021 Dec 29). 55. H. Wen, H. Luo, M. Yang, S. M. A. Augustino, D. Wang, S. Mi, Y. Guo, Y. Zhang, W. Xiao, Y. Wang*, Y. Yu*.Genetic parameters and weighted single-step genome-wide association study for supernumerary teats in Holstein cattle. J. Dairy Sci. 2021 Nov;104(11):11867-11877 https://doi.org/10.3168/jds.2020-19943. 56. Siqian Chen, Shuli Liu, Siyuan Mi, Wenlong Li, Shengli Zhang, Xiangdong Ding*, Ying Yu*. Comparative analyses of sperm DNA methylomes among three commercial pig breeds reveal vital hypomethylated regions associated with spermatogenesis and embryonic development. Frontiers in Genetics. 2021 Oct 6;12:740036. doi: 10.3389/fgene.2021.740036. eCollection 2021. 57. Fengxia Zhang, Siqian Chen, Ting Yang, Hong Ao, Liwei Zhai, Qianjun Li, Kai Xing, Yibing Liu, Huatao Liu, Ying Yu*, Chuduan Wang*. Novel DNA methylation markers of PRRSV-specific antibodies and their intergenerational transmission from pregnant sows to piglets. Gene. 2021. 801, 145831. https://doi.org/10.1016/j.gene.2021.145831 58. Xiaoshuo Wang, Hong Ao, Minyan Song, Lijing Bai, Weiyong He, Chuduan Wang*, Ying Yu*. Identification of DNA methylation regulated novel host genes relevant to inhibition of virus replication in porcine PK15 cell using double stranded RNA mimics and DNA methyltransferase inhibitor. 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F4ac 产肠毒素大肠杆菌菌液上清对仔猪小肠上皮细胞的免疫刺激作用. 中国农业科学, 2014, 47(4): 779-785 50. 周传丽,刘铮铸,俞英*,张勤*. 仔猪小肠黏膜上皮细胞体外分离培养及鉴定. 中国农业科学, 2011, 44(21):4516-4524. 51. 董易春,刘铮铸,周传丽,潘登科,张 勤*,俞 英*,转抗仔猪腹泻候选基因FUT1克隆猪的效率分析及分子鉴定,中国畜牧杂志,2014,50( 9): 1-5. 52. 窦金焕,李仲淑*,王雅春,董易春,周传丽,刘铮铸,张勤, 俞英*,转抗仔猪腹泻基因FUT1克隆猪印记基因IGF2的表达分析,中国畜牧兽医,2014, 41(12): 255-260. 53. 王晓铄#,俞英#,刘会杰,肖丽,翟立维,敖红,王楚端*,基于表达谱芯片挖掘抗猪瘟病毒相关基因及其在不同猪瘟抗体水平下的表达差异, 畜牧兽医学报,2014, 45 (1):14-22. 54. 王晓,解小莉,王胜,钱梦樱,马裴裴,张沅,孙东晓,刘剑锋,丁向东,姜力,王雅春,张毅,张胜利,张勤*,俞英*,中国荷斯坦牛乳房炎易感性及抗性的全基因组关联分析,畜牧兽医学报,2013,12:1907-1912. 55. 樊利军,张梦泽,韦艺媛,卢胜明,王小珂,王珑,姚毅,王雅春*,俞英*. 奶牛金黄色葡萄球菌乳腺炎小鼠模型的建立. 实验动物科学,2011,28(6):1-6. 56. 何阳花, 俞英*, 张沅*. 拷贝数变异与疾病的关系及其在动物抗病育种中的应用前景. 遗传, 2008, 11: 1385-1391. 57. 马裴裴,俞英*,张沅*,张勤,王雅春,孙东晓,张毅. 中国荷斯坦牛SCC变化规律及其与产奶性状之间的关系,畜牧兽医学报,2010,41:1529-1535. 58. 俞英,王雅春,孙东晓,张毅,张沅. 动物育种教学新体系的建立与探索. 教育教学论坛. 2010,36:111-112. 59. 韦艺媛,王新,郝斐,俞英*. 奶牛乳房炎致病型耐甲氧西林金黄色葡萄球菌的分离鉴定,中国乳业,2011,1: 50-51. 60. 徐庆磊,Serafino M.A.Augustino,米思远,王雅春,黄锡霞,张勤,俞英*. 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