周磊

简      历

周磊, 教授/博士生导师（Ph.D., DVM）

农业农村部动物流行病学重点实验室

国家猪繁殖与呼吸综合征专业实验室

中国农业大学动物医学院

1.    Sun Weifeng, Wu Weixin, Fang Xinyu, Ge Xinna, Zhang Yongning, Han Jun, Guo Xin, Zhou Lei* ^co, Yang Hanchun* ^co. Disruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection. Cell Mol Life Sci. 2024 May 28;81(1):240.

2.      Gao Peng^co, ZhouLei^co, WuJiajun^co, Weng Wenlian, Wang Hua, Ye Miaomiao, Qu Yajin, Hao Yuxin, Zhang Yongning, Ge Xinna, Guo Xin, Han Jun, and Yang Hanchun. Riding apoptotic bodies for cell–cell transmission by African swine fever virus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2023, Vol. 120 | No. 48, November 28.

3.      Cao Xiaoyu, Ge Xinna, Zhang Yongning, Guo Xin, Han Jun, Zhou Lei* ^co, Yang Hanchun* ^co. Genetic Characteristics of Three Single-Farm-Isolated Porcine Reproductive and Respiratory Syndrome Viruses with Novel Recombination among NADC30-Like, JXA1-Like, and QYYZ-Like Strains. Transboundary and Emerging Diseases, vol. 2023, Article ID 8871321.

4.      Xingzhen Tang, Cong Wang, Weifeng Sun, Weixin Wu, Shaohui Sun, Jin Wan, Guangshan Zhu, Nini Ma, Xiaoping Ma, Ruihua Xu, Qiushi Yang, Yindi Dai, Lei Zhou.Evaluating anti-viral effect of Tylvalosin tartrate on porcine reproductive and respiratory syndrome virus and analyzing the related gene regulation by transcriptomics. Virol J. 2023 Apr 26;20(1):79.

5.      Tan, Shaoyuan                  , Wu, Weixin, Ge, Xinna, Zhang, Yongning, Han, Jun, Guo, Xin,Zhou Lei* ^co, Yang Hanchun* ^co. A novel strategy to attenuate porcine reproductive and respiratory syndrome virus by inhibiting viral replication in the target pulmonary alveolar macrophages via hematopoietic-specific miR-142. One Health Advances, 2023.Apirl 1(1), 3.

6.      Wang Jingjing, Zhang Mengsi, Cui Xiaocun, Gao Xiang, Sun Weifeng, Ge Xinna, Zhang Yongning, Guo Xin, Han Jun, Zhou Lei* ^co, Yang Hanchun* ^co. Attenuated Porcine Reproductive and Respiratory Syndrome Virus Regains Its Fatal Virulence by Serial Passaging in Pigs or Porcine Alveolar Macrophages To Increase Its Adaptation to Target Cells. Microbiol Spectr. 2022 Oct 11:e0308422. doi: 10.1128/spectrum.03084-22.

7.      Wang Yang, Ge Xinna; Zhang Yongning, Han Jun, Guo Xin, Zhou Lei*, Yang Hanchun. Construction of a Porcine Reproductive and Respiratory Syndrome Virus with Nanoluc Luciferase Reporter: a Stable and Highly Efficient Tool for Viral Quantification Both In Vitro and In Vivo. Microbiol Spectr. 2022 Aug 31;10(4):e0027622.  

8.      Sun Weifeng, Wu Weixin, JiangNan, Ge Xinna,  Zhang Yongning, Han Jun, Guo Xin* ^co, Zhou Lei* ^co, Yang Hanchun. Highly Pathogenic PRRSV-Infected Alveolar Macrophages Impair the Function of Pulmonary Microvascular Endothelial Cells. Viruses 2022, 14, 452.

9.      Wu Weixin, Ge Xinna; Zhang Yongning, Han Jun, Guo Xin, Zhou Lei* ^co, Yang Hanchun* ^co. Evolutionary Patterns of Codon Usage in Major Lineages of Porcine Reproductive and Respiratory Syndrome Virus in China, Viruses. 2021. 13, no. 6: 1044.

10.    Zhou Lei, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021;9:362.

11.    Zhou X, Ge X, Zhang Y, Han J, Guo X, Chen Y, Zhou Lei * ^co Yang, H* ^co. Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model. Virulence. 2021;12:1011-21.

12.    Zhou, X^co, Zhou Lei^co, , Zhang, P, Guo, X., Han, J. and Yang, H. A strain of porcine deltacoronavirus: Genomic characterization, pathogenicity and its full‐length cDNA infectious clone. Transbound Emerg Dis. 2020; 00: 1– 17. https://doi.org/10.1111/tbed.13862

13.    Su, J., Zhang, X., He, B., Ge, X., Han, J., Zhou Lei * ^co, Guo, X* ^co. and Yang, H., Identification of three site mutations in nonstructural protein 1β, glycoprotein 3 and glycoprotein 5 that correlate with increased interferon α resistance of porcine reproductive and respiratory syndrome virus. Veterinary Microbiology, 2019. p.108395.

14.    Zhang, Z^co., Zhou Lei^co，Ge, X., Guo, X., Han, J. and Yang, H., 2018. Evolutionary analysis of six isolates of porcine reproductive and respiratory syndrome virus from a single pig farm: MLV-evolved and recombinant viruses. Infection, Genetics and Evolution, 66, pp.111-119.

15.    Jiang Nan; Jin Huan; Li Yi; Ge Xinna; Han Jun; Guo Xin; Zhou Lei *; Yang Hanchun, 2017. Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes , PLos One, 12(11): 0~e0188946

16.    Cui Zhengzhi; Niu Shuaishuai; Liu Jingjing; Xu Lei; Dai Yunping; Li Ning; Kang Youmin; Zhang Linlin *^co; Zhou Lei*^co ; Yu Shuyang*^co ,2017. Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice , Science Bulletin, 62(24): 1634~1636

17.   Gao, Xiang, Dongliang Li, Jingyi Zhao, Farong Xu, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang, and Zhou Lei*, 2016. Complete genome sequence of porcine epidemic diarrhea virus from an outbreak in a vaccinated farm in Shandong, China. Genome announcements 4, no. 4 (2016): e00619-16.

18.   Zhou Lei^co, Yang Beina^co, Xu Lei., Jin, H., Ge, X., Guo, X.,  Yang, H. 2017. Efficacy evaluation of three modified-live virus vaccines against a strain of porcine reproductive and respiratory syndrome virus NADC30-like. Veterinary Microbiology.

19.   Han Jun^co, Zhou Lei^co , Yang Hanchun, 2017.Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Veterinary Microbiology (2017).

20.   Zhou Lei^co, Zichun Wang^co, Yuping Ding, Xinna Ge, Xin Guo, Hanchun Yang，2015. NADC30-like Strain of Porcine Reproductive and Respiratory Syndrome Virus, China. Emerging infectious diseases 21.12 (2015): 2256.

21.    Li Y^co,Zhou Lei^co, Zhang JL, Ge XN, Zhou R, Zheng HG, Geng G, Guo X, Yang HC. 2014. NSP9 and NSP10 Contribute to the Fatal Virulence of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Emerging in China. PLoS pathogens. 10, e1004216.

22.    Li Wang^co, Zhou Lei^co, Han Zhang, Yan Li, Xinna Ge, Xin Guo, Kangzhen Yu, Hanchun Yang,2014Interactome Profile of the Host Cellular Proteins and the Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus. PLoS ONE 9(6): e99176. doi:10.1371/journal.pone.0099176 

23.   Zhou Lei, Xiaorong Yang, Yuan Tian, Xinna Ge, Xin Guo, Hanchun Yang, 2014 Genetic Diversity Analysis of Genotype 2 Porcine Reproductive and Respiratory Syndrome Viruses Emerging in Recent Years in China. BioMed Research International, vol. 2014, Article ID 748068, 13 pages, 2014. doi:10.1155/2014/748068

24.   Zhou Lei, Ni Y-Y, Piñeyro P, Cossaboom CM, Subramaniam S, Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J. 2013.Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes. PLoS ONE 8(6): e66645. doi:10.1371/journal.pone.0066645

25.    Zhou Lei, Ni, Y.-Y., Piñeyro, P., Sanford, B., Cossaboom, C., Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J., 2012. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. Virology434, 96-109.

26.    Zhou, Lei, Yang, H., 2010. Porcine reproductive and respiratory syndrome in China. Virus research154, 31-37.

27.  Zhou, Lei^co, Chen, S^co., Zhang, J., Zeng, J., Guo, X., Ge, X., Zhang, D., Yang, H., 2009a. Molecular variation analysis of porcine reproductive and respiratory syndrome virus in China. Virus research145, 97-105.

28.    Zhou, Lei^co, Zhang, J.^co, Zeng, J., Yin, S., Li, Y., Zheng, L., Guo, X., Ge, X., Yang, H., 2009b. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. Journal of virology83, 5156-5167.

国际会议报告:

1.     Lei Zhou, Hanchun Yang. “Present Status of PRRSV Diversity in China”. PRRSCon Meeting , Ghent Belgium. 15-16 May,2014.

2.     Lei Zhou, Xingchen Wang, Hanchun Yang. “Nsp9 and Nsp10 contribute to the pathogenicity of  genotype 1 PRRSV Isolated in China” PRRSCon Meeting , Ghent Belgium. 15-16 May,2014.

3.     Lei Zhou, Yan-Yan Ni, Pablo Pin ˜ eyro1, Caitlin M. Cossaboom, Sakthivel Subramaniam, Brenton J. Sanford, Barbara A. Dryman, Yao-Wei Huang, Xiang-Jin Meng Broadening the Heterologous Cross-Neutralizing Antibody Inducing Ability of Porcine Reproductive and Respiratory Syndrome Virus by Breeding the GP4 or M genes Confference of  Reseachers Work on Animal Diseases， Chicago IL, United States. December 8-10, 2013.  Oral presenter.

4.     Lei Zhou, Xingchen Wang, Hanchun Yang. “Genomic characterization and pathogenicity of a genotype 1 PRRSV Isolated in China” PRRSCon Meeting , Loti, Italy.  21-22 November, 2013.

5.     Lei Zhou, Ni, Y.-Y., Piñeyro, P., Sanford, B., Cossaboom, C., Dryman, B., Huang, Y.-W., Cao, D.-J., Meng, X.-J.. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. No .157. Confference of  Reseachers Work on Animal Diseases， Chicago IL, United States. December 3-4, 2012.  Oral presenter.

6.     Dan Liu, Rong Zhou, Lei Zhou, XinGuo, XinnaGe, Hanchun Yang. The recombination between two strains of PRRSV in vivo results in the generation of recombinant virus with higher pathogenicity. P67, International PRRS Symposium, Chicago IL, United States. 2-3 ,December, 2011.  Oral presenter.

7.     Zhou Lei, Zhang, J., Zeng, J., Yin, S., Li, Y., Zheng, L., Guo, X., Ge, X., Yang, H., 2009b. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. New generation researchers in pig viral diseases: building bridges from labs to policy and the farm, Madrid, Spain July, 2011. Oral presenter

获奖情况：

科研项目：

ASFV感染对靶细胞吞噬杀伤功能的影响及机制 [十四五国家重点研发项目子课题]

北方地区非洲猪瘟综合防控技术集成与示范 [十三五国家重点研发项目子课题]

学术兼职：

-畜牧兽医学会养猪学分会副秘书长

-中国动物疫控制中心疫病净化评估专家

-Virus Research 杂志编委

-《中国兽医杂志》副主编